Registration Dossier
Registration Dossier
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EC number: 441-810-8 | CAS number: 116313-85-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 441-810-8
- EC Name:
- -
- Cas Number:
- 116313-85-0
- Molecular formula:
- C7H5NO5
- IUPAC Name:
- 3,4-dihydroxy-5-nitrobenzaldehyde
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Amount / concentration applied:
- 66 mg
- Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
- Irritant / corrosive response data:
- Changes not fully reversible within 21 days
Any other information on results incl. tables
Common visible permanent areas to opalising areas of opacity were found. Formation of escar of the cornea was observed
after 24, 48 and 72 h p.a. during which a vascularisation of the cornea (common growing in of vessels for 2 to 3 mm) was
found 7, 14 and 21 days p.a..
An orange discolouring of the cornea and iris which prevented the assessment of the iris reactions was observed 1 h p.a..
Slight conjunctival irritation was observed 1 h upto 7 days p.a. during which a minimal conjunctival irritation was observed 14 d p.a..
Other adverse effects:
pale appearance of the nicitating membrane, cornea-bulla and abnormal formed eyeball.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
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