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EC number: 200-090-3 | CAS number: 51-34-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-08-26 to 2016-04-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 29.82 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 8.8
- Conclusions:
- It can be assumed that about 41% of the dissolved test item underwent degradation within 259 hours at pH 9 and 20°C. The determined solubility of 29.82 g/L represents 59% of the dissolved test item as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).
Reference
Table 1: Preliminary Test Procedure
01 g soluble in ´x´ mL of water |
0.1 |
0.5 |
1 |
2 |
10 |
100 |
>100 |
Approx. solubility (g/L) |
>1000 |
1000 to 200 |
200 to 100 |
100 to 50 |
50 to 10 |
10 to 1 |
<1 |
Table 2: Preliminary test result in deionised water (1000 g/L to 5 g/L)
Test item [mg] |
Total volume of water [mL] |
Time of shaking [min] |
remarks |
Approx. solubility [g/L] |
103 |
0.10 |
10 |
not dissolved completely |
< 1000 |
0.50 |
10 |
not dissolved completely |
< 200 |
|
1.0 |
10 |
not dissolved completely |
< 100 |
|
2.0 |
10 |
not dissolved completely |
< 50 |
|
10 |
10 |
not dissolved completely |
< 10 |
|
20 |
10 |
dissolved completely |
5 - 10 |
Therefore, the approximate solubility of the test item was estimated to be between 5 – 10 g/L at 20°C.
Table 3: Results of the water solubility of Scopolamine in deionised water being in equilibrium with atmospheric carbon dioxide
Samping Time [h] |
Calculated Concentration Flask 1 [mg/l] |
Calculated Concentration Flask 2 [mg/l] |
pH value |
91 |
27.84 |
27.85 |
8.91 |
116 |
29.29 |
28.13 |
8.85 |
140 |
29.53 |
29.17 |
8.82 |
162 |
30.34 |
30.51 |
8.82 |
239 |
31.44 |
31.39 |
8.70 |
259 |
31.46 |
30.83 |
8.69 |
|
|||
Overall Mean |
29.82 |
8.80 |
|
Standard Deviation |
1.38 |
0.09 |
|
RSD* [%] |
4.6 |
1.0 |
*RSD – relative standard deviation
The two independent flasks do not differ by more than 15% from each other.
The Abiotic Degradation study (Study No. S15-04511) showed degradation of Scopolamine at pH 7 (DT50 = 3904 h) and pH 9 (DT50 = 339 h) at 20°C.
As the solubility of Scopolamine in water was determined over a period of 259 hours and the pH value of the test item solution was determined to be 8.80, it has to be considered that a certain amount of Scopolamine underwent degradation.
It can be assumed that about 41% of the dissolved test item underwent degradation within 259 hours at pH 9 and 20°C. The determined solubility of 29.82 mg/l represents 59% of the dissolved test item.
Description of key information
The Abiotic Degradation study (study report S15 -04511; CSR section 4.1.1.1. Hydrolysis) showed degradation at pH 7 (DT50 = 3918 h / 163 d) and pH 9 (DT50 = 339 h / 14 d) at 20°C. As the solubility in water was determined over a period of 259 hours and the pH value of the test item solution was determined to be 8.80, it has to be considered that a certain amount of Scopolamine underwent degradation. It can be assumed that about 41% of the dissolved test item underwent degradation within 259 hours at pH 9 and 20°C. The determined solubility of 29.82 g/L represents 59% of the dissolved test item as determined by flask method according to Regulation EC No. 440/2008 Method A.6., OECD Test Guideline 105 (1995).
Key value for chemical safety assessment
- Water solubility:
- 29.82 g/L
- at the temperature of:
- 20 °C
Additional information
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