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EC number: 214-881-6 | CAS number: 1205-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 March 2006 to 23 March 2006
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- The skin irritation potential of three batches of the test material was assessed in the rabbit.
- GLP compliance:
- no
Test material
- Reference substance name:
- α-methyl-1,3-benzodioxole-5-propionaldehyde
- EC Number:
- 214-881-6
- EC Name:
- α-methyl-1,3-benzodioxole-5-propionaldehyde
- Cas Number:
- 1205-17-0
- Molecular formula:
- C11H12O3
- IUPAC Name:
- 3-(1,3-benzodioxol-5-yl)-2-methylpropanal
- Details on test material:
- - Appearance: Light yellow liquid, Clear Liquid
- Stability: There was no apparent change in the physical state of the test material during administration
- Storage conditions of test material: Room temperature, protected from exposure to light
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: JW
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 male animals were exposed to three batches of test material
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The test material was removed with lukewarm water
- Time after start of exposure: 4 hours
SCORING SYSTEM
The Draize scoring system was used. Reactions were assessed 1, 24, 48 and 72 hours after test material application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- score of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- score of all 3 animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Irritant / corrosive response data:
- At the 24, 48 and 72 hour time points, no rabbit showed any reaction to the test material with regard to erythema and oedema formation. All scores were 0.
Any other information on results incl. tables
Table 1: Summary of Scores for the First Batch of Test Material
Animal number |
Observation |
Time (hours) |
|||
1 |
24 |
48 |
72 |
||
101 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
102 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
103 |
Erythema |
1 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
Table 2: Summary of Scores for the Second Batch of Test Material
Animal number |
Observation |
Time (hours) |
|||
1 |
24 |
48 |
72 |
||
101 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
102 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
103 |
Erythema |
1 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
Table 3: Summary of Scores for the Third Batch of Test Material
Animal number |
Observation |
Time (hours) |
|||
1 |
24 |
48 |
72 |
||
101 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
102 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
|
103 |
Erythema |
1 |
0 |
0 |
0 |
Oedema |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the conditions this study, the test material is not classified as a dermal irritant in accordance with EU criteria.
- Executive summary:
A study was conducted to assess the potential of the test material to cause irritation to the skin of rabbits using methodology similar to that outlined in the standardised guideline OECD 404.
The skin irritation potential of three batches of the test material was assessed in 3 male JW rabbits. The dose level administered was 0.5 mL/2.5 x 2.5 cm site. Observations were made at 1 hour after exposure and then every 24 hours for a total duration of 72 hours. The Draize scoring system was used to determine the degree of skin reaction.
At the 24, 48 and 72 hour time points, no rabbit showed any reaction to the test material with regard to erythema and oedema formation. All scores were 0.
Under the conditions this study, the test material is not classified as a dermal irritant in accordance with EU criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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