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EC number: 258-556-7 | CAS number: 53445-37-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial plants
Administrative data
- Endpoint:
- toxicity to terrestrial plants: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994-12-06 to 1994-12-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 208 (Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test)
- Version / remarks:
- (1984)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2,4(or 2,4,4)-trimethyladipic acid
- EC Number:
- 258-556-7
- EC Name:
- 2,2,4(or 2,4,4)-trimethyladipic acid
- Cas Number:
- 53445-37-7
- Molecular formula:
- C9H16O4
- IUPAC Name:
- 2,2,4-trimethylhexanedioic acid; 2,4,4-trimethylhexanedioic acid
- Details on test material:
- 2,2,4(or 2,4,4)-Trimethyladipic acid of Hüls AG, produced 25 March 1992. Sample from continuous production, storage tank FA 975.
Purity 90 % w/w, sample ID 3630/81389, sample No. 1324/920707
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- not specified
- Details on preparation and application of test substrate:
- Preparation of test medium: 0.178 g test substance + 20 g quartz sand + 1580 g soil mixed thoroughly in a plastic bag
Test organisms
open allclose all
- Species:
- Brassica alba
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- no further information
- Species:
- Lepidum sativum
- Plant group:
- Dicotyledonae (dicots)
- Details on test organisms:
- no further information
- Species:
- Triticum aestivum
- Plant group:
- Monocotyledonae (monocots)
- Details on test organisms:
- no further information
Study design
- Test type:
- seedling emergence toxicity test
- Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
Test conditions
- Test temperature:
- 23-25 °C
- pH:
- 6.0 (control) / 6.8 (test)
- Details on test conditions:
- SOIL CHARACTERISTICS
- Commercial substrate of LUFA (Speyer, Germany), properties:
- Sieved at 0.5 cm mesh width
- < 1.5 % organic carbon
- 10-20 % particles < 20 µm
- pH value 5-7.5
- water storage capacity 35.3 g / 100 g
TEST SYSTEM
- Culturing apparatus: Black plastic flower pots, height approx. 6 cm, diameter approx. 8 cm (top) / approx. 6 cm (bottom), filled with 100 g dry
test medium
- Number of replicates: 4 replicates with 5 seeds each
- Addition of water: Initially approx. 60 % of capacity, once during study as required
- Atmospheric humidity: Average 92 % - Photoperiod: 16 hours light (1200-2000 Lux) / 8 hours dark (50-100 Lux)
TEST PARAMETERS
- Emergence: Number of plants / number of seeds - Growth: Mean weight of plant parts above the soil surface as determined directly at end of study - Nominal and measured concentrations:
- 100 mg/kg soil dry weight (nominal)
- Reference substance (positive control):
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Species:
- Brassica alba
- Duration:
- 17 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- seedling emergence
- Remarks:
- and growth
- Species:
- Lepidum sativum
- Duration:
- 17 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- seedling emergence
- Remarks:
- and growth
- Species:
- Triticum aestivum
- Duration:
- 17 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- seedling emergence
- Remarks:
- and growth
- Details on results:
- Weights of the single plants after 17 days ranged from 264 mg to 441 mg for the controls and from 125 to 492 mg for the treated plants.
No significant differences between the control and the treated plants were detected.
Any other information on results incl. tables
- Test: 18/20 = 90 %
- Control: 18/20 = 90 %
Growth
- Test: 179 +/- 46 mg
- Control: 162 +/- 39 mg
2. Lepidum sativum
Emergence
- Test: 18/20 = 90 %
- Control: 20/20 = 100 %
Growth
- Test: 77 +/- 18 mg
- Control: 79 +/- 17 mg
3. Triticum aestivum
Emergence
- Test: 18/20 = 90 %
- Control: 17/20 = 85 %
Growth
- Test: 333 +/- 90 mg
- Control: 344 +/- 52 mg
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The seedling emergence and the growth of Brassica alba, Lepidium sativum and Triticum aestivum were not affected at the tested concentration (100 mg 2,2,4(or 2,4,4)-trimethyladipic acid/kg dw).
- Executive summary:
The study (Hüls AG 1995) assessed effects on seedling emergence and early growth of higher plants following exposure to 2,2,4(or 2,4,4)-trimethyladipic acid in the soil according to OECD TG 208 (1984). Seeds of Brassica alba, Lepidium sativum and Triticum aestivum were placed in contact with soil treated with the test substance (100 mg/kg dry weight) and evaluated for effects after 17 days. No effects on the seedling emergence and the growth of the three test species were observed during this limit test.
The study was assessed as "reliable without restrictions".
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