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EC number: 203-597-8 | CAS number: 108-59-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Dimethyl malonate
- EC Number:
- 203-597-8
- EC Name:
- Dimethyl malonate
- Cas Number:
- 108-59-8
- Molecular formula:
- C5H8O4
- IUPAC Name:
- dimethyl malonate
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Small white Russian, Chbb: HM, SPF
- Details on test animals or tissues and environmental conditions:
- Weight at study initiation: 2 - 3 kg
Test system
- Controls:
- yes, concurrent no treatment
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- >= 0 - <= 1
- Max. score:
- 1
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- >= 0 - <= 0.33
- Max. score:
- 0.33
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- >= 0 - <= 0.67
- Max. score:
- 0.67
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.67
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24, 48, 72 hours
- Score:
- >= 0 - <= 1.67
- Max. score:
- 1.67
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- other: 24, 48, 72 hours
- Score:
- >= 0 - <= 1.33
- Max. score:
- 1.33
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- other: 24, 48, 72 hours
- Score:
- >= 0 - <= 1
- Max. score:
- 1
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 1.33
- Irritation parameter:
- other: conjunctivae redness score
- Basis:
- animal #1
- Time point:
- other: 24,48,72 hours
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- other: conjunctivae redness score
- Basis:
- animal #2
- Time point:
- other: 24,48,72 hours
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- other: conjunctivae redness score
- Basis:
- animal #3
- Time point:
- other: 24,48,72 hours
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- other: conjunctivae redness score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 2
- Irritation parameter:
- other: conjunctivae chemosis score
- Basis:
- animal #1
- Time point:
- other: 24,48,72 hours
- Score:
- >= 0 - <= 1.67
- Max. score:
- 1.67
- Irritation parameter:
- other: conjunctivae chemosis score
- Basis:
- animal #2
- Time point:
- other: 24,48,72 hours
- Score:
- >= 0 - <= 1.33
- Max. score:
- 1.33
- Irritation parameter:
- other: conjunctivae chemosis score
- Basis:
- animal #3
- Time point:
- other: 24,48,72 hours
- Score:
- >= 0 - <= 1.33
- Max. score:
- 1.33
- Irritation parameter:
- other: conjunctivae chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- ca. 1.44
- Irritant / corrosive response data:
- 1 h p.a.: Medium grade erythema of the conjunctivae and slight
corneal opacity as well as excretion of a white exsudate from
the treated eyes was observed in all 3 animals. 2 animals had
additionally a very slight edema, one a marked edema.
24 h p.a.: All 3 animals showed medium grade erythema and
marked edema of the conjunctivae, indications of an irritaiton
of the iris with intact pupil reaction. The cornea was
slightly opaque (in 2 animals the whole area was affected, in
1 animal about half of the area). Exsudation was still
observed in one animal.
48 h p.a.: The medium grade erythema was unchanged in all
animals, while edema was reduced in 2 animals. 2 animals still
showed iridal irritation while it was reduced in one animal.
In 2 animals corneal opacity had increased slightly.
Exsudation was still observed in one animal.
72 h p.a.: The medium grade erythema was unchanged in all
animals, while edema was reversed. Iridal irritation was still
observed in one animal. Slight corneal opacity was seen in 2animals (covering one and 3 quarts of
the surface
respectively) while in 1 animal corneal opacity wa still
unchanged.
6 d p.a.: Corneal and iris reactions were reversed completely
in all animals, very slight conjunctival irritation and
chemosis was observed in 2 animals.
8 d p.a.: All effects were reversible by day 8
Applicant's summary and conclusion
- Interpretation of results:
- other: irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- Cornea: turbidity
Iris: normal
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