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EC number: 201-854-9 | CAS number: 88-73-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
o-chloronitrobenzene is considered not irritating to the skin and to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The skin irritation potential of 1 -chloro-2 -nitrobenzene was also evaluated in a study performed comparable to OECD guideline 404. The intact and abraded skin flank of six Himalayan rabbits was exposed to 0.5 ml 10% (dissolved in sesame oil) test material for 24 hours under semi-occlusive conditions. The rabbits were observed for 72 hours. Skin reactions were assessed using the Draize scheme according to Fed.Reg.38, No.187, p.27019, 1973, § 1500.41 after 24, 48 and 72 hours after substance application. The mean erythema scores after 24 hours were 1.0 for both the intact and abraded skin in 4/6 animals. The edema scores were 0.0 for the intact and abraded skin after 24, 48 and 72 hours. All treated skin sites appeared normal at the 48-hour observation (Hoechst AG, 1975).
The eye irritation potential of 1 -chloro-2 -nitrobenzene was investigated in 6 Himalyan rabbits according to the FDA guideline (federal register, Vol 38, No. 187, 1973). 100 mg undissolved test substance was applied into the conjunctival sac of one eye of each animal. The eyes were rinsed after 24 hours application of the test substance. The eye irritation reactions were examined and scored using the Draize method 1, 7 and 24h after application. After 1 hour 1 -chloro-2 -nitrobenzene induced slight conjunctival redness in all animals (4/6 score=1 and 2/6 score=2). These effects were reversible within 24 h. The mean scores over 1, 7 and 24 h were 0.0 for corneal opacity, iritis, chemosis and conjunctivae in all animals. Therefore no classification is required (Hoechst AG, 1975).
In another study comparable to OECD guideline 405 the eye irritation potential of 1 -chloro-2 -nitrobenzene was investigated in 2 albino rabbits. 50 mg test substance was applied into the conjunctival sac of the right eye of each animal. No eye irritating effects (conjunctivae and cornea) were observed throughout the test and after 7 days observation time (Groening, Bayer AG, 1975).
Based on the study results and according to EU classification criteria, the test substance is not to be classified.
Justification for classification or non-classification
No classification required.
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