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Diss Factsheets
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EC number: 431-460-4 | CAS number: 10061-02-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.2; OECD 403 (1989)
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 431-460-4
- EC Name:
- -
- Cas Number:
- 10061-02-6
- Molecular formula:
- C3H4Cl2
- IUPAC Name:
- (1E)-1,3-dichloroprop-1-ene
- Test material form:
- liquid
- Details on test material:
- Batch no: TR 88001
Also know as ST088/098
Constituent 1
Test animals
- Species:
- other: rat, Sprague-Dawley Crl:CD(SD)BR
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Vehicle:
- other: None.
- Details on inhalation exposure:
- Head only
- Duration of exposure:
- 4 h
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 5.098 mg/L air
- 95% CL:
- 4.54 - 6.092
- Exp. duration:
- 4 h
- Mortality:
- Male: 3.859 mg/L; Number of animals: 5; Number of deaths: 1
Male: 4.449 mg/L; Number of animals: 5; Number of deaths: 1
Male: 4.98 mg/L; Number of animals: 5; Number of deaths: 3
Male: 6.36 mg/L; Number of animals: 5; Number of deaths: 3
Female: 3.859 mg/L; Number of animals: 5; Number of deaths: 1
Female: 4.449 mg/L; Number of animals: 5; Number of deaths: 0
Female: 4.98 mg/L; Number of animals: 5; Number of deaths: 3
Female: 6.36 mg/L; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: 3.859 mg/l: On days 2 and 3 all animals exhibited piloerection, lethargy and abnormal fur. One female exhibited cold/hunched posture and loss of condition on day 5 and/or 6. Two animals died on days 4 and 6
- Gross pathology:
- Effects on organs:
Two from dose group 3.859 mg/l, one from dose group
4.449 mg/l, six from dose group 4.980 mg/l and eight from
dose group 6.360 mg/l rats died or were killed in extremis
during the course of the study. The most consistent necropsy
findings were dark/red and inflated lungs suggestive of
local effects on the respiratory tract. Yellow/dark contents
were also found in the stomach of five animals, and the
kidneys of two decedents were pale; possibly suggesting
effects outwith the respiratory tract.
Most treated animals surviving to study termination were
either unremarkable at necropsy or had minor lesions similar
to those of the controls. One dose group 4.449 mg/l female
had a pale zone in the corticomedullary region in the
kidney. Taken together with the pale kidneys in two of the
decedents, this was also suggestive of effects on the
kidneys.
Any other information on results incl. tables
Migrated information
On the basis of the test results given below and in conformity with the criteria given in Annex VI of the Directive, the substance should be not classified X
Criteria used for interpretation of results: EU
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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