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EC number: 226-882-9 | CAS number: 5533-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Remarks:
- The skin irritation in vivo (according to OECD TG 404) was performed before the new guidelines were initiated.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was carried out between 28 November and 9 December 2005.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-methoxy-4-(methoxymethyl)phenol
- EC Number:
- 226-882-9
- EC Name:
- 2-methoxy-4-(methoxymethyl)phenol
- Cas Number:
- 5533-03-9
- Molecular formula:
- C9H12O3
- IUPAC Name:
- 2-methoxy-4-(methoxymethyl)phenol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: SPF albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: stock Chbb:HM from Charles River Deutschland GmbH, D-88353 Kisslegg
- Age at study initiation: 7-18 months
- Weight at study initiation: 2.3 - 2.8 kg bw
- Housing: During a pre-period of at least one week and throughout the experiment the rabbits were caged individually in PPO cages (floor area: 2576 sq. cm) with perforated floor.
- Diet: A pelleted complete rabbit diet "Altromin 2123" from Altromin, D-32791 Lage, Lippe, was available ad libitum. Analyses for major nutritive components and relevant possible contaminants were performed.
- Water: The animals had free access to bottles with dometic quality drinking water acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth. Analyses for relevant possible contaminants were performed.
- Acclimation period: At least one week
ENVIRONMENTAL CONDITIONS
- Temperature: 20 ± 3°C
- Humidity: at least 30 % and not exceeding 70%
- Air changes: 10 times/hour
- Photoperiod (hrs dark / hrs light): 12/12.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- Test material
- Applied volume: 0.5 ml
- Concentration: undiluted - Duration of treatment / exposure:
- 4-hour exposure period
- Observation period:
- After the exposure, the observation was performed immediately and at 1h, 24 h, 48 h and 72 h.
- Number of animals:
- A total of 3 animals were used, treated with the test substance.
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- Coverage: The test item was applied on a 16-layer gauze patch and put on an animal. Adhesive Gothaplast tape (2.5 cm and 5 cm wide) served as the semi-occlusive securing.
REMOVAL OF TEST SUBSTANCE
- Washing: After the period of 4 hours of exposure, the patch was removed and the treated skin was cleaned with mild soap and lukewarm water.
SCORING SYSTEM:
- Method of calculation: erythema and oedema formation were scored and the mean values for both were calculated
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: immediately after application
- Score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 1 h
- Score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2 and #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: immediately after application and after 1h
- Score:
- 0
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- All three rabbits at the readings of 24, 48 and 72 h were free of any signs of skin irritation. The mean individual erythema scores were 0 for all three rabbits. Also the mean individual oedema scores were 0 for all three rabbits.
Only one rabbit showed reaction immediately after the termination of exposure. It was a very slight erythema and it remained until 1 h after termination of exposure. - Other effects:
- No other effects were noted:
- No acute clinical symptoms were observed
- No mortality occurred
- No adverse effect on the body weight gain was observed
Any other information on results incl. tables
Rabbit no. |
Exposure |
Erythema formation |
Oedema formation |
|||||||||
0 |
1 |
24 |
48 |
72 |
0 |
1 |
24 |
48 |
72 |
|||
3104 |
3 min |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
1 h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
4 h |
1 |
1 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
||
3300 |
4 h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
|
3297 |
4 h |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Remarks:
- According to EU CLP 1272/2008 and its amendments.
- Conclusions:
- In a skin irritation study with rabbits, performed according to OECD 404 (2005), the substance was not irritating.
- Executive summary:
The substance was tested in a skin irritation test in 3 rabbits in accordance with OECD TG 404 (2005) test guideline. No irritation was observed: the mean value for both erythema and edema from gradings at 24, 48 and 72 hours after patch removal was 0 in all animals. This effect does not result in classification and labelling for EU CLP.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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