Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloro-α,α,α-trifluorotoluene
EC Number:
202-642-9
EC Name:
3-chloro-α,α,α-trifluorotoluene
Cas Number:
98-15-7
Molecular formula:
C7H4ClF3
IUPAC Name:
1-chloro-3-(trifluoromethyl)benzene
Test material form:
liquid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: HOECHST AG, Kastengrund, SPF-Zucht
- Age at study initiation: male ca. 7 wks, female ca. 8 wks
- Weight at study initiation: males 178 g - 207 g (average 194 g); females: 166 g - 196 g (average 179 g)
- Fasting period before study: about 16 hours
- Housing: 5 animals per makrolon cage
- Diet: Altromin 1324 rat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 50 +/- 20
- Photoperiod: 12 hrs dark / 12 hrs light

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Doses:
3150 and 5000 mg/kg bw
No. of animals per sex per dose:
5 males and 5 females per dose
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of weighing: weekly
- Necropsy of survivors performed: yes, macroscopical examination
- Other examinations performed: clinical signs
Statistics:
LD50 Evaluation; 95% confidence interval

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
95% CL:
841 - 1 550
Mortality:
3150 mg/kg bw: 0/5 male animals and 0/5 female animals
5000 mg/kg bw: 1/5 male animals and 2/5 female animals
Clinical signs:
other: In addition to nonspecific poisoning symptoms, impairment of breathing, movement apparatus and reflex, as well as drowsiness, tear flow, blood-crusted eyelids and muzzles, narrowed palpebral fissures and diarrhea occurred.
Gross pathology:
Animals which survived:
no macroscopical findings.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under the conditions of the present aucte oral toxicity study 3-Chlorobenzotrifluoride revealed a LD50 value of > 5000 mg/kg bw for male and female animals.