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Diss Factsheets
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EC number: 258-649-2 | CAS number: 53585-53-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
In accordance with column 2 of REACH Annex X, the carcinogenicity study (required in section 8.9.1) does not need to be conducted as the substance does not have a widespread dispersive use; the human exposure is low; the substance is not classified as mutagen category 2, and there is no evidence from the repeated dose studies that the substance is able to induce hyperplasia and/or preneoplastic lesions.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
From a 90-day and a 120-day toxicity study, the toxicity of dibenzyltoluene is known to be limited to liver (in particular hypertrophy of hepatocytes) and slight kidney effects after prolonged exposure at dose levels of 100 and 500 mg/kg bw. No carcinogenic or pre-carcinogenic effects were observed after 90 days or 120 days oral exposure.
In addition, negative results were obtained from a series of in vitro and in vivo genotoxicity tests assessing gene mutation and chromosomal damage. Moreover, the studies performed to assess the enzymatic induction and peroxisome proliferation show that dibenzyltoluene is only a slight inducer.
Therefore, no carcinogenic classification is required for dibenzyltoluene.
Additional information
Results from a 90-day toxicity study indicate that the toxicity of dibenzyltoluene is limited to liver (hypertrophy of hepatocytes) and increased kidney weights in male and female rats after prolonged exposure at the mid and high dose exposure (100 and 500 mg/kg bw). In a 120-day toxicity study, the compound induced hypertrophy of centrilobular (and sometimes mediolobular) hepatocytes in most animals associated with a slight increase in liver weights in both sexes and a slight increase in cholesterol levels in males at 500 mg/kg bw, whereas the animals of the mid dose exposure (50 mg/kg bw) were unaffected.
Hypertrophy of hepatocytes in the 100 and 500 mg/kg bw exposures of the studies is isolated and not a specific histological sign of pre-carcinogenic effect. Moreover the consistently negative results from the series of in vitro and in vivo genotoxicity tests assessing gene mutation and chromosomal damage do not suggest any cause for concern with respect to carcinogenicity. In addition, the studies performed to assess the enzymatic induction and peroxisome proliferation show that dibenzyltoluene is only a slight inducer. Therefore there is presumption on absence of a carcinogenic potential for dibenzyltoluene.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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