Registration Dossier
Registration Dossier
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EC number: 236-412-4 | CAS number: 13360-57-1
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity
- Remarks:
- subcutaneous
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethylsulphamoyl chloride
- EC Number:
- 236-412-4
- EC Name:
- Dimethylsulphamoyl chloride
- Cas Number:
- 13360-57-1
- Molecular formula:
- C2H6ClNO2S
- IUPAC Name:
- N,N-dimethylsulfamoyl chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- peanut oil
- Analytical verification of doses or concentrations:
- no
- Post exposure period:
- until natural death, moribound animals were sacrificed.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Basis:
nominal conc.
- No. of animals per sex per dose:
- 25 male and 25 female animals per dose.
10 and 100 mg/kg bw - Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
No differences in state and behaviour between treated and control animals.
No differences in body weight development between treated and control animals.
Survival time in treated animals significantly and dose related shortend in treated animals.
Tumors - fibrosarcoma - at the treatment site were developed in a higher rate and earlier as in control animals:
10 mg/kg : male 22 treated vs. 4 control
female 11 treated vs. 1 control of 25 each
100 mg/kg: male 22 treated vs. 4 control
female 17 treated vs. 1 control of 25 each
Appearance of the tumors from week 30 on in treated animals vs. week 95 in control animals.
Number and distribution of other malign and benign tumors did not show a treatment related increase.
Applicant's summary and conclusion
- Conclusions:
- A clear local cancerogenic effect at the application site at higher dosage.
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