Registration Dossier
Registration Dossier
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EC number: 203-142-3 | CAS number: 103-76-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic algae.
Key value for chemical safety assessment
- EC50 for marine water algae:
- 329 mg/L
Additional information
The toxic effects of hydroxyethylpiperazine (HEP; CAS 103-76-4) on aquatic algae and cyanobacteria were studied in two growth inhibition tests. Eide-Haugmo et al. (2009/2012) studied the effect on the marine algae Skeletonema costata. The growth inhibition test was performed according to ISO 10253. The test conditions were static. Test concentrations were not analytically verified, but are assumed to be stable: 1) the substance is not readily biodegradable, 2) it is not expected to evaporate from the water surface based on a low Henry’s Law constant (HLC =2.37E-8 Pa*m³/mol), and 3) adsorption is not expected due to a low adsorption coefficient (log Koc = 1.2 at pH 7). Based on nominal test concentrations, the 72-h ErC50 was determined to be 329 mg/L.
A supporting study was conducted according to OECD TG 201A with hydroxyethylpiperazine as part of a mixture (approximately 38% HEP; BASF SE, 2012, report no.: 60E0722/11E129). Pseudokirchneriella subcapitata was used as test species. Based on analytically verified nominal test concentrations the 72 -h ErC10 and the 72-h ErC50 were determined to be >120 mg/L (based on test substance mass without correction for purity = mixture). For the evaluation, based on the fraction of HEP in the mixture, the 72-h ErC10 of HEP and the ErC50 were calculated to be > 45.6 mg/L (worst-case approach, not considering potential mixture toxicity). The ErC10 value was used for further evaluation of long-term effects. However, the short-term toxicity are assessed based on the data for the marine algae.
In conclusion, the substance is with high probability acutely not harmful to algae.
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