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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
3-ethenyl-5-methyl-1,3-oxazolidin-2-one
EC Number:
809-852-5
Cas Number:
3395-98-0
Molecular formula:
C6H9NO2
IUPAC Name:
3-ethenyl-5-methyl-1,3-oxazolidin-2-one
Details on test material:
- Name of test material (as cited in study report): 5-Methyl-3-vinyloxazolidin-2-one
- Analytical purity: 99.5 area % (GC-area-%)
- Lot/batch No.: DEIMLIB-00070

Study design

Analytical monitoring:
yes
Buffers:
- pH: 4, 7, 9
- Composition of buffer: pH 4 (Bernd Kraft; citric acid, sodium chloride, sodium hydroxide), pH 7 (Bernd Kraft; phosphate mixture), pH 9 (Bernd Kraft; boric acid, sodium hydroxide, potassium chloride), acetonitrile (Fluka), pH=4.008 (Bernd Kraft), pH=9.184 (Bernd Kraft)

Results and discussion

Transformation products:
yes
Identity of transformation productsopen allclose all
No.:
#1
No.:
#2
Reference
Reference substance name:
Unnamed
IUPAC name:
Methyl alcohol
Inventory number:
InventoryMultipleMappingImpl [inventoryEntryValue=EC 200-659-6]
CAS number:
67-56-1
Molecular formula:
CH4O
Molecular weight:
32.042
SMILES notation:
CO
InChl:
InChI=1/CH4O/c1-2/h2H,1H3
Details on hydrolysis and appearance of transformation product(s):
The reaction of the test item with water under neutral or acidic conditions is well known. No hydrolysis products could be observed in any test (pH 4, pH 7 and pH 9) under the analytical conditions applied. The results which were calculated out of measurements at 20°C for pH 4 and pH 7 are similar to the calculated values from using the Arrhenius data.
Dissipation DT50 of parent compoundopen allclose all
pH:
4
Temp.:
20 °C
DT50:
28.8 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Half-lives measured
pH:
4
Temp.:
50 °C
DT50:
1.5 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Half.lives measured
pH:
4
Temp.:
60 °C
DT50:
0.7 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Half-lives measured
pH:
7
Temp.:
20 °C
DT50:
1 952 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Half-lives measured
pH:
7
Temp.:
50 °C
DT50:
99.1 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Half-lives measured
pH:
7
Temp.:
60 °C
DT50:
42.4 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Half-lives measured
pH:
7
Temp.:
70 °C
DT50:
21.1 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Half-lives measured
pH:
9
Temp.:
50 °C
Remarks on result:
other: no hydrolysis could be observed (<10% in 5 days)

Any other information on results incl. tables

Half-lives at 20°C and 25°C, calculated from the measured values:

 pH value Temperature   t1/2
 pH 4 20°C   24.0 h
 pH 4 25°C 14.6 h 
 pH 7 20°C   1446.2 h
 pH 7 25°C  888.3 h

Applicant's summary and conclusion

Validity criteria fulfilled:
yes