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EC number: 214-426-1 | CAS number: 1126-79-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The similarity of the acute toxicity of all three trophic levels was apparent in the full suite of available experimental data. The predicted and experimental EC/LC50 values for butyl phenyl ether ranged from 2.1 - 5.77 mg/L across all species and trophic levels. Since the acute invertebrate toxicity of 2.1 mg/L was the lowest toxicity value, this was used to derive the predicted no effect concentration in the aquatic environment for butyl phenyl ether.
Additional information
Butyl phenyl ether acute toxicity to fish was determined in a single fish species, the fathead minnow (Pimephales promelas). Two fathead minnow 96 -hr LC50 values for butyl phenyl ether are available; one 96-hr LC50 was determined with juvenile fish (i.e. 5.77 mg/L), while the other 96-hr LC50 value was determined with larval fathead minnows (i.e. >5.88 mg/L). Additionally, a 7-day LC50 value with larval fathead minnows is available for butyl phenyl ether. Since the 7-day LC50 value was the lowest for butyl phenyl ether, this value of 3.28 mg/L was used as the key value in the chemical safety assessment for fish acute toxicity.
The acute toxicity of butyl phenyl ether was experimentally determined in two species of invertebrates, Daphnia magna and Ceriodaphnia dubia. The 24-hr LC50 for butyl phenyl ether with C. dubia was 3.2 mg/L, and the 24-hr LC50 for butyl phenyl ether with D. magna was 2.1 mg/L. A daphnia acute toxicity QSAR was conducted and the estimated 48-hr LC50 for Daphnia sp. was 3.3 mg/L. Since the experimental LC50 value with D. magna was the lowest value, this value was used as the key value for the assessment of acute invertebrate toxicity.
The 72 h EC50 of butyl phenyl ether was evaluated in one species of green algae, Pseudokirchneriella subcapitata. The EC50 and NOEC values (based on growth rate) for Pseudokirchneriella subcapitata exposed to butyl phenyl ether over a 72-hour static exposure period were 2.84 mg/L and 0.183 mg/L, respectively. The acute toxicity of butyl phenyl ether was also estimated via QSAR. The EC50 for algae via QSAR estimation was 4.4 mg/L, which was in good agreement with the experimental results. Since the experimental results were slightly lower than the QSAR results, and since there was greater certainty associated with the experimental results, the value of 2.84 mg/L was used as the key value for the assessment of acute algae toxicity.
The similarity of the acute toxicity of all three trophic levels was apparent in the full suite of available experimental data. The predicted and experimental EC/LC50 values for butyl phenyl ether ranged from 2.1 - 5.77 mg/L across all species and trophic levels. Since the acute invertebrate toxicity of 2.1 mg/L was the lowest toxicity value, this was used to derive the predicted no effect concentration in the aquatic environment for butyl phenyl ether.
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