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EC number: 811-367-9 | CAS number: 11073-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2016-09-15 to 2016-12-05
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 13 April 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source: H.C. Starck GmbH, Batch No.of test material: 150273V2
- Expiration date of the lot/batch:July 2021
- Purity test date: >98%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature, dry, dark and tightly closed
- Stability under test conditions: stable
- Solubility and stability of the test substance in the solvent/vehicle: 4 mg/L (according to OECD 105: loading rate of 100 mg/L and stirring for 72 h at 30 °C)
OTHER SPECIFICS: White Powder - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0 mg/L (NC), 100 mg/L (A)
- Sampling method: At the start of the test (0 h), the test solutions NC and A were sampled before division to the test vessels (each group: 4 samples of 10 mL). After 24 h exposure, all replicates of NC and A were sampled (each group: 4 samples of
10 mL). At the end of the test (48 h), all replicates from NC and A were sampled (each group: 4 samples of 10 mL).
- Sample storage conditions before analysis: The samples were filtered (0.45 μm syringe filter, Whatman), filled in plastic centrifuge tubes and stored (< 4 weeks) in the fridge (5 °C ± 3 °C). Of each treatment, one of the samples from 0 h, 24 h and 48 h was sent to the analytical laboratory (ASG) and analysed. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The stock solution was prepared by adding 24.7 mg test item to 250 mL test medium and shaking for 72 h using an overhead shaker at 21.4 - 22.3 °C in the dark. Subsequently, the test item solution was allowed to settle for ca. 0.5 h before use in the test as single test item loading rate. Into each test vessel, 40 mL test item solution and test medium (NC) was transferred, respectively. Four replicates with five daphnids each, were prepared for the test treatment and the negative control.
- Eluate: ISO 6341 medium
- Controls: ISO 6341 medium
- Medium: According to OECD 202, for testing substances containing metals, media containing chelating agents should be avoided. The test was performed with ISO 6341 medium which does not contain EDTA. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna (Strauss)
- Source: clone breeding of the Federal Environment Agency, department IV 2.4, Berlin, and has been cultivated at Hydrotox GmbH since October 2012.
- Age at study initiation: The test organisms used were 0.25 - 23.25 h old at the start of the test.
- Feeding during test: none
- Feeding during cultivation (on workdays): Desmodesmus subspicatus algae corresponding to 0.1 mg C × daphnid-1 × day-1; food type: Desmodesmus subspicatus algae
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Test temperature:
- 19.4 - 20.6 °C
- pH:
- The pH was 7.6 - 7.8 in the control and 7.7 - 7.9 in the test item treatment
- Dissolved oxygen:
- The dissolved oxygen concentration was 7.9 - 8.0 mg/L in the control and 7.8 - 8.1 mg/L in
the test item treatment. - Salinity:
- not applicable
- Nominal and measured concentrations:
- Nominal: 0 mg/L (NC) , 100 mg/L (A)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beakers 50 mL, Schott, Mainz
- Fill volume: 40 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates):4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ultrapure water
- Culture medium different from test medium: M4 Medium
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16/8 h
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilisation
RANGE-FINDING STUDY
- Test concentrations:A preliminary test without GLP was performed before start of this GLP-study. Nominal loading rates of 50, 100 and 200 mg/L test item were tested and showed no effects on the mobility of the test organisms.
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- LOELR
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- LOELR
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The immobility in the control was reported as 0 % after 24 h and after 48 h.
The immobility in the treatment group was 0% after 24 h and 5% after 48 h. - Validity criteria fulfilled:
- yes
- Remarks:
- Immobilisation of the test organisms in the control at the end of the test was 0 % and therefore ≤ 10 %. Dissolved oxygen concentration in the control and the test item treatment at the end of the test was ≥ 8.0 mg/L and therefore ≥ 3 mg/L.
- Conclusions:
- The LOELR of Gadolinium zirconium oxide to Daphnia magna exceeds 100 mg/L, the NOELR exceeds or equals 100 mg/L.
- Executive summary:
The 48-h-acute toxicity of Gadolinium zirconium oxide to Daphnia magna was studied under static conditions in accordance with the OECD Guideline 202 (April 2004) and under GLP. The test design was chosen as limit test, as a pre-test with test substance concentrations of 50, 100 and 200 mg/L showed no growth inhibition.
Within the limit test daphnids were exposed to the test chemical at a loading rate of 100 mg/L for 48 hr. Mortality/immobilisation and sub-lethal effects were observed daily. The LOELR was determined as > 100 mg/L, the NOELR as >= 100 mg/L. Sub-lethal effects were not reported.
Due to the poor water solubility, the measured Gd- and Zr-concentrations in the test item treatment were 10 -20 µg/L and below the limit of quantification (< 1 μg/L), respectively.
Based on the results of this study, Gadolinium zirconium oxide would not be classified for aquatic toxicity in accordance with the CLP classification system (Regulation (EC) No 1272/2008).
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Test organism age: Neonates
Test type: Static
LOELR > 100 mg/L
NOELR >= 100 mg/L
Endpoint(s) effected: Immobilitsation
Reference
The reported immobility during the test is presented in table 2. The values for the calculated LOELR and NOELR are displayed in table 3.
Table 2: Immobility [%] after 24 h and 48 h exposure.
Nominal test item concentration [mg/L] | Immobility [%] | |
24 h | 48 h | |
NC | 0 | 0 |
A (100 mg/L) | 0 | 5 |
Table 3: Effect loading rates.
Lowest/No Observed Effect Loadring Rate | Nominal test item loading rate [mg/L] | |
24 h | 48 h | |
LOELR | > 100 | > 100 |
NOELR | ≥ 100 | ≥ 100 |
The dissolved oxygen concentration was
7.9 - 8.0 mg/L in the control and 7.8 - 8.1 mg/L in the test item
treatment.
The temperature during the exposure was 19.4 - 20.6 °C (required 18 - 22
°C, constant within ± 1 °C).
The measured concentration of Gd and Zr in the reference sample for quality assurance was within the acceptable tolerance range of ± 20 %.
The measured Gd-concentrations in the test
item treatment were 10-20 μg/L and the Zr-concentrations were below the
limit of quantification (< 1 μg/L). The Gd- and Zr-concentrations in the
control were below the limit of quantification.
Description of key information
The 48 h acute toxicity of Gadolinium zirconium oxide to aquatic invertebrates (Daphnia magna) was investigated in a study, according to GLP and OECD 202 under static conditions. The Lowest/No Observed Loading Rates are as follows: NOELR (24 h) ≥ 100 mg/L, LOELR (24 h) > 100 mg/L, NOELR (48 h) ≥ 100 mg/L, LOELR (48 h) > 100 mg/L.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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