Registration Dossier
Registration Dossier
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EC number: 204-288-0 | CAS number: 118-93-4
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-07-24 to 1997-08-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline compliant sudy report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2'-hydroxyacetophenone
- EC Number:
- 204-288-0
- EC Name:
- 2'-hydroxyacetophenone
- Cas Number:
- 118-93-4
- Molecular formula:
- C8H8O2
- IUPAC Name:
- 1-(2-hydroxyphenyl)ethan-1-one
- Details on test material:
- - Name of test material (as cited in study report): 2-Hydroxyacetophenone
- Substance type: organic
- Physical state: clear pale yellow liquid
- Expiration date of the lot/batch: 30 June 1997
- Storage condition of test material: at room temperature in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan lnterfauna UK Ltd, Huntingdon, Cambridgeshire, UK
- Age at study initiation: 10 - 12 wks
- Weight at study initiation: 2.2 - 2.7 kg
- Housing: individually
- Diet: ad libitum, standard laboratory rabbit diet (STANRAB (P) (SQC) Rabbit Diet from Special Diets Services)
- Water: ad libitum, tap water
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 - 22
- Humidity (%): 47 - 79
- Air changes (per hr): 10 - 15
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorso-lumbar region (approx. 100 mm x 100 mm)
- Type of wrap if used: waterproof dressing
REMOVAL OF TEST SUBSTANCE
- Washing: with warm water (30 - 40 °C)
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amounts applied: 1.713 mL/kg bw - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: at least twice daily; weighing was performed once a week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: One female showed soft to liquid feces on Days 10 and 11. No clinical signs were observed in the other animals.
- Gross pathology:
- No gross internal lesions were observed during necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
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