Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-447-7 | CAS number: 141-01-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data of read across chemicals
- Justification for type of information:
- Data is from handbook or collection of data
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- WoE was prepared to determine the effect of test chemical on the mortality of fishes.
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: WoE 2: Danio rerio (previous name: Brachydanio rerio), WoE 3: Lepomis microlophus
- Details on test organisms:
- TEST ORGANISM
WoE 2:
- Common name:Zebrafish
WoE 3:
- Common name:Bluegill
- Age at study initiation (mean and range, SD):Fingerling
- Length at study initiation (length definition, mean, range and SD):38-76 MM - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Remarks on exposure duration:
- 96 hours in WoE 3
- Test temperature:
- WoE 3: 19.5 to 20.5 °C
- Dissolved oxygen:
- WoE 3: > 60 %
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 245 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: WoE 2
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 300 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: WoE 3
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the mortality of fishes Brachydanio rerio (Zebrafish) and Lepomis microlophus (Bluegill) due to the test chemical exposure for 48 hours and 96 hours, the lethal concentration i.e. LC50 value was determined to be in the range of 245 mg/l to > 300 mg/l.
- Executive summary:
Summarized result from the various experimental sources for the determination of effect of test chemical on the mortality of fishes are as mentioned below:
An acute toxicity of test chemical was determined on fish. Test conducted under the static system. Brachydanio rerio (Zebrafish) was used as a test organism. Exposure period of 48 hrs was provided. Mortality were used a key parameter for the effect’s measurement. After the exposure period of 48 hours, mortality was calculated and the median lethal concentration (LC50) value was observed to be at 245 mg/L.
Above data further supported by the study from secondary sources. Principle of this study was to determine the effect of test chemical on the mortality of fishes. Lepomis microlophus (Bluegill) was used as a test organism. Test conducted under the static system for 96 hours. Fingerling age with 38-76 MM length fishes was selected for the study. Test temperature 19.5 to 20.5 °C and dissolved oxygen > 60 % were maintained. Based on the mortality of fishes Lepomis microlophus (Bluegill) due to the test chemical exposure for 96 hours, the lethal concentration i.e. LC50 value was determined to be > 300 mg/l. Thus, on the basis of LC50 value, test chemical considers to be nontoxic and not classified as per the CLP classification criteria.
Thus, on the basis of above all studies and effects observations, test chemical consider to be nontoxic and not classified as per the CLP classification criteria.
Reference
Description of key information
Based on the mortality of fishes Brachydanio rerio (Zebrafish) and Lepomis microlophus (Bluegill) due to the test chemical exposure for 48 hours and 96 hours, the lethal concentration i.e. LC50 value was determined to be in the range of 245 mg/l to > 300 mg/l.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 245 mg/L
Additional information
Summarized result from the various experimental sources for the determination of effect of test chemical structurally and functionally similar read across chemicals on the mortality of fishes are as mentioned below:
An acute toxicity of test chemical was determined on fish. Test conducted under the static system. Brachydanio rerio (Zebrafish) was used as a test organism. Exposure period of 48 hrs was provided. Mortality were used a key parameter for the effect’s measurement. After the exposure period of 48 hours, mortality was calculated, and the median lethal concentration (LC50) value was observed to be at 245 mg/L.
Above data further supported by the study from secondary sources. Principle of this study was to determine the effect of test chemical on the mortality of fishes. Lepomis microlophus (Bluegill) was used as a test organism. Test conducted under the static system for 96 hours. Fingerling age with 38-76 MM length fishes was selected for the study. Test temperature 19.5 to 20.5 °C and dissolved oxygen > 60 % were maintained. Based on the mortality of fishes Lepomis microlophus (Bluegill) due to the test chemical exposure for 96 hours, the lethal concentration i.e. LC50 value was determined to be > 300 mg/l. Thus, on the basis of LC50 value, test chemical considers to be nontoxic and not classified as per the CLP classification criteria.
Thus, on the basis of above all studies and effects observations, test chemical consider to be nontoxic and not classified as per the CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.