Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 246-426-2 | CAS number: 24717-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 September to 12 October 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- The test design given in the guideline was modified to a slow-stirring design. Time and temperature conditions were based on the flask method.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss Federal Office of Public Health
- Type of method:
- other: Slow-stirring design
- Remarks:
- Since the test item is a liquid with a density < 1, the OECD guideline was adapted to a slow-stirring design, in order to avoid formation of an emulsion. Time and temperature conditions were based on the flask method.
- Key result
- Water solubility:
- 0.385 mg/L
- Temp.:
- 20 °C
- pH:
- 7.02
- Conclusions:
- A water solubility value of 0.385 ± 0.016 mg/L (at 20 °C, pH = 7.02) was determined for the test substance according to OECD 105.
Reference
Results
After a stirring time of 24 hours, 48 hours and 72 hours, respectively, at 30 °C, the samples were equilibrated for another 24 hours at 20 °C. Afterwards, a duplicate aliquot of the samples was taken through a cock at the bottom of the flask. The samples were analysed by HPLC with UV-detection. The results of the individual measurements are shown in the table below.
Results of the Water Solubility of [test item].The tabulated values represent rounded results, obtained by calculation using the exact raw data.
Sample No. |
Stirring time at 30 °C [hours] |
Measured Concentration [mg/L] |
Mean Value [mg/L] |
Overall Mean ± Std.Dev. [mg/L] |
24-1 |
24 |
0.172 |
0.173 |
|
24-2 |
24 |
0.173 |
||
48-1 |
48 |
0.226 |
0.266 |
|
48-2 |
48 |
0.227 |
||
72-1 |
72 |
0.383 |
0.386 |
0.385 ± 0.016 (RSD: 4.1 %) |
72-2 |
72 |
0.389 |
||
96-1 |
96 |
0.366 |
0.385 |
|
96-2 |
96 |
0.404 |
||
120-1 |
120 |
0.286 |
0.301 |
|
120-2 |
120 |
0.317 |
||
144-1 |
144 |
0.236 |
0.258 |
|
144-2 |
144 |
0.280 |
After 72 hours stirring, no plateau was achieved and the values were still increasing. The test was repeated using longer equilibration times.
After 96 hours the values were similar as for 72 hours. After 96 hours they started to decrease. Thus, the water was saturated after 72 hours.
Final results
In this study, the water solubility of the test item was determined using a slow-stirring experiment. The time / temperature conditions for the test were based on the OECD Guideline for the Testing of Chemicals, No. 105: Water Solubility, shake flask method.
The water solubility of the test item was found to be 0.385 ± 0.016 mg/L, at an average pH of 7.02.
The maximum solubility was achieved after 72 hours.
Description of key information
Water solubility: 0.385 ± 0.016 mg/L at 20 °C, pH = 7.02 (OECD 105, Slow-stirring design)
Key value for chemical safety assessment
- Water solubility:
- 0.385 mg/L
- at the temperature of:
- 20 °C
Additional information
Since the test item is a liquid with a density < 1, the OECD guideline was adapted to a slow-stirring design, in order to avoid formation of an emulsion. Time and temperature conditions were based on the flask method.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.