Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-396-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The dataset for aquatic toxicity is not complete for Reaction product of Isooctadecanoic acid, ester with oxybis[propanediol] (CAS 73296-86-3). In order to fulfil the standard information requirements, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from a structurally related substance was conducted. In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for aquatic toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across). With regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity.
Di(isooctadecanoic) acid, diester with oxydi(propanediol) (CAS 67938-21-0) was selected as the source substance. The source substance is one main component of the UVCB substance. Thus, it is considered to be suitable for the assessment of the target substance.
The toxicity to fish and algae was investigated using the source substance Di(isooctadecanoic) acid, diester with oxydi(propanediol) (CAS 67938-21-0). For toxicity to aquatic invertebrates a reliable guideline study for the target substance itself is available. All studies were performed according to internationally accepted guidelines and GLP (except for fish). Since the target and the source substance are poorly soluble in water, water accommodated fractions (WAFs) were prepared (if possible) for the test solutions in all tests (except for fish testing).
The acute toxicity to fish was investigated in a static test design performed comparably to OECD 203. Leuciscus idus melanotus was exposed to four concentrations in the range of 1 to 500 mg/L (nominal) under static conditions for 96 h. No mortality was observed after 96 h. Thus, a LC50 (96 h) > 500 mg/L (nominal) was derived.
The acute toxicity to aquatic invertebrates was investigated for the target substance itself and the suitable source substance according to OECD 202. The obtained EL50 (48 h) values from both studies were in the same order of magnitude, supporting the selected read-across approach. In the key study with the target substance D. magna was exposed to five nominal loading rate WAFs between 6.25 – 100 mg/L for 48 h in a static exposure regime. The obtained EL50 (48 h) was > 50 mg/L (nominal). The supporting study with the source substance Di(isooctadecanoic) acid, diester with oxydi(propanediol) confirmed the result of the key study. The derived EL50 (48 h) was > 50 mg/L. All effect values were based on the nominal loading rates of the test item. In both studies (key and supporting) immobilization of > 50% was recorded at the highest loading rate of 100 mg/L. Since the substances are surface active and form micelles in contact with water, this loading rate was excluded from assessment (see water solubility study in IUCLID section 4.8). There is strong evidence that the observed effects are physical effects rather than intrinsic effects due to micelle formation at least at the highest loading rate.
One OECD guideline study conducted with the structurally related source substance Di(isooctadecanoic) acid, diester with oxydi(propanediol) is available to cover the endpoint for the toxicity of the target substance to aquatic algae. The unicellular freshwater green alga Desmodesmus subspicatus was exposed to five nominal loading rates for 72 h. No inhibition of growth was recorded and the derived ErL50 and ErL10 (72 h) were > 250 mg/L (nominal). The corresponding NOELR and LOELR values were ≥ 250 mg/L (nominal) and > 250 mg/L (nominal), respectively.
In conclusion, the target substance is not likely to cause effects to aquatic organisms. No effects were observed in the available studies up to the solubility limit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.