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EC number: 207-924-5 | CAS number: 501-52-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: refer below principle
- Principles of method if other than guideline:
- The reduction of aromatic acid i.e 3-phenylpropionic acid by the hyperthermophilic organism Pyrococcus furiosus was investigated.
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - IUPAC name: 3-phenylpropanoic acid
- Molecular formula: C9H10O2
- Molecular weight: 150.176 g/mol
- Smiles: c1(CCC(O)=O)ccccc1
- InChI: 1S/C9H10O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,10,11)
- Substance type: Organic
- Physical state: solid - Analytical monitoring:
- yes
- Details on sampling:
- The substrate concentration was 1 mM before inoculation.
- Vehicle:
- not specified
- Test organisms (species):
- other: Pyrococcus furiosus
- Details on inoculum:
- P. furiosus (DSM 3638) was grown anaerobically at 90°C in a basic medium.Yeast extract, cysteine, vitamins, and trace elements were added a Potato starch (5 g/1) was used as a carbon and energy source. Cells were grown in 100 ml bottles containing 50 ml medium,which was flushed with N2/CO2 (80/20) before inoculation. During growth, the bottles were shaken continuously at 200 rev./min. The medium was inoculated with a 2% preculture.
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 25 h
- Remarks on exposure duration:
- experimental conditions occured for 18 - 25 h after
- Hardness:
- No data
- Test temperature:
- 90 deg.C
- pH:
- 6.8-7.0
- Dissolved oxygen:
- No data
- Salinity:
- No data
- Conductivity:
- No data
- Nominal and measured concentrations:
- 1 mM which is equivalent to 150.1 mg/l
- Details on test conditions:
- The start of growth the pH was 6.8 - 7.0 and was not adjusted during the experiment.
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 25 h
- Dose descriptor:
- EC50
- Effect conc.:
- 150.1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: In batch conversions 3-phenylpropionic acid was reduced with yield 69%.
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In batch conversions experiment the test chemical 3-phenylpropionic acid was reduced with the highest yield (69%) with Substrate concentrations 1 mM which is equivalent to 150.1 mg/l.
- Executive summary:
The reduction of aromatic acid i.e 3-phenylpropionic acid by the hyperthermophilic organism Pyrococcus furiosus was investigated.
P. furiosus (DSM 3638) was grown anaerobically at 90°C in a basic medium.Yeast extract, cysteine, vitamins, and trace elements were added a Potato starch (5 g/1) was used as a carbon and energy source. Cells were grown in 100 ml bottles containing 50 ml medium,which was flushed with N2/CO2 (80/20) before inoculation. During growth, the bottles were shaken continuously at 200 rev./min. The medium was inoculated with a 2% preculture.
Analytical method used as HPLC on a Nucleosil 100 C18 5U(Alltech, Laarne, Belgium) column. A Waters 600 controller and pump and a Waters 996 photodiode array detector were used (all Millipore, Milford, USA).Methanol/1% acetic acid was used as eluent and the analysis was isocratic.
1mM substrate concentration was used in experiment which is equivalent to 150.1 mg/l.
In batch conversions 3-phenylpropionic acid was reduced with the highest yield (69%) with Substrate concentrations 1 mM which is equivalent to 150.1 mg/l.
Reference
Yield of alcohols from aromatic acid i.e 3-phenylpropanoic acid reduced byP. furiosus in batch culture.
Substrate |
Product |
Yield (%) |
3-Phenylpropionic acid |
3-Phenyl-1-propanol |
68.7 ±4.2 |
Description of key information
In batch conversions experiment the test chemical 3-phenylpropionic acid was reduced with the highest yield (69%) with Substrate concentrations 1 mM which is equivalent to 150.1 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 150.1 mg/L
Additional information
The reduction of aromatic acid i.e 3-phenylpropionic acid by the hyperthermophilic organism Pyrococcus furiosus was investigated.
P. furiosus (DSM 3638) was grown anaerobically at 90°C in a basic medium.Yeast extract, cysteine, vitamins, and trace elements were added a Potato starch (5 g/1) was used as a carbon and energy source. Cells were grown in 100 ml bottles containing 50 ml medium,which was flushed with N2/CO2 (80/20) before inoculation. During growth, the bottles were shaken continuously at 200 rev./min. The medium was inoculated with a 2% preculture.
Analytical method used as HPLC on a Nucleosil 100 C18 5U(Alltech, Laarne, Belgium) column. A Waters 600 controller and pump and a Waters 996 photodiode array detector were used (all Millipore, Milford, USA).Methanol/1% acetic acid was used as eluent and the analysis was isocratic.
1mM substrate concentration was used in experiment which is equivalent to 150.1 mg/l.
In batch conversions 3-phenylpropionic acid was reduced with the highest yield (69%) with Substrate concentrations 1 mM which is equivalent to 150.1 mg/l.
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