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EC number: 205-160-7 | CAS number: 134-85-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Remarks:
- Read across substance
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Authoritive database
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritive database
- Title:
- Skin irritation for CAS NO: 98-73-7
- Author:
- IFA (GESTIS)
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)
- Reference Type:
- review article or handbook
- Title:
- European Union Risk Assessment Report 4-TERT-BUTYLBENZOIC ACID
- Author:
- European Union Risk Assessment Report-RAPPORTEUR [GERMANY]
- Year:
- 2 009
- Bibliographic source:
- European Union Risk Assessment Report-RAPPORTEUR [GERMANY]- July 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Skin irritation study was conducted on 6 New Zealand albino rabbits to assess the irritation potential of 4-tert-Butylbenzoic acid
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-tert-butylbenzoic acid
- EC Number:
- 202-696-3
- EC Name:
- 4-tert-butylbenzoic acid
- Cas Number:
- 98-73-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 4-Tert-Butylbenzoic acid (PTBBA)
- Test material form:
- solid
- Details on test material:
- Name of the test chemical:4-Tert-Butylbenzoicacid
Molecular formula: C11H14O2
Molecualr Weight:178.23 g/mol
Substance Type: Organic
Physical State: Solid
InChI: 1S/C11H14O2/c1-11(2,3)9-6-4-8(5-7-9)10(12)13/h4-7H,1-3H3,(H,12,13)
Constituent 1
- Specific details on test material used for the study:
- Name of the test chemical:4-Tert-Butylbenzoicacid
Molecular formula: C11H14O2
Molecualr Weight:178.23 g/mol
Substance Type: Organic
Physical State: Solid
InChI: 1S/C11H14O2/c1-11(2,3)9-6-4-8(5-7-9)10(12)13/h4-7H,1-3H3,(H,12,13)
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No Data Available
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- No Data Available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, and 72 hours after the removal of the dressing.
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No known signs of skin irritation were observed
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- No cutaneous reaction was detected. Hence, 4-Tert-butylbenzoic acid was considered to be not irritating to the rabbit’s skin.
- Executive summary:
Skin irritation study was performed in 6 New Zealand albino rabbits in accordance with EU test guideline B4 to assess the irritation potential of the test substance 4 -Tert-butylbenzoic acid (CAS no.: 98 -73 -7, E.C. no.: 202 -696 -3). Single application of 500 mg of 4 -tert-butylbenzoic acid moistened with water was applied to a clipped area of 6 New Zealand albino rabbits and was held in contact with the skin for 4 hours by a semi-occlusive dressing. The skin reactions were read at 1, 24, 48, and 72 hours after the removal of the dressing. The overall irritation score was noted to be 0. No cutaneous reaction was detected in any of the animals. Hence, the test substance 4 -Tert-butylbenzoic acid was considered to be not irritating to the rabbit’s skin.
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