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EC number: 231-323-7 | CAS number: 7492-66-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short term toxicity to fish:
From ACD (Advanced Chemistry Development)/I-Lab predictive module (v5.0.0.184) the predicted Median Lethal Concentration (LC50, mg/L) of the test substance 1,1-diethoxy-3,7-dimethylocta-2,6-diene for fish species Pimephales promelas was reported to be 7.2 mg/l on the basis of mortality effects.
The Reliability Index (RI) for the prediction was reported to be0.54( As per model substance have moderate and high reliability ifRI > 0.5).Thus reported RII value indicate it has moderate reliability. And LC50 value indicate that the test substance 1,1-diethoxy-3,7-dimethylocta-2,6-diene considered as harmful to aquatic organisms and thus can be classified in aquatic chronic category 2 as per the CLP classification criteria.
Short term toxicity on aquatic invertebrates
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 1,1-diethoxy-3,7-dimethylocta-2,6-diene (7492-66-2). EC50 value was estimated to be 12.5 mg/l for Daphnia magna for 48 hrs duration. Based on the value, 1,1-diethoxy-3,7-dimethylocta-2,6-diene (7492-66-2) was considered to be toxic to aquatic invertebrates, hence it can be considered to be classified in chronic category 3 as per the CLP regulations.
Toxicity to aquatic algae and cyanobacteria
Using the OECD QSAR toolbox version 3.3 (2017) with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic algae and cyanobacteria was predicted for target substance 1,1-diethoxy-3,7-dimethylocta-2,6-diene
(CAS no. 7492 -66 -2). EC50 value was estimated to be 4.89 mg/l for Desmodesmus subspicatus for 72 h duration. Based on this value it can be concluded that the substance 1,1 -diethoxy-3,7 -dimethylocta-2,6 -diene is considered to be toxic to aquatic environment and can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.
Additional information
Short term toxicity to fish
From ACD (Advanced Chemistry Development)/I-Lab predictive module (v5.0.0.184) the predicted Median Lethal Concentration (LC50, mg/L) of the test substance 1,1-diethoxy-3,7-dimethylocta-2,6-diene for fish species Pimephales promelas was reported to be 7.2 mg/l on the basis of mortality effects.
The Reliability Index (RI) for the prediction was reported to be0.54( As per model substance have moderate and high reliability ifRI > 0.5).Thus reported RII value indicate it has moderate reliability. And LC50 value indicate that the test substance 1,1-diethoxy-3,7-dimethylocta-2,6-diene considered as harmful to aquatic organisms and thus can be classified in aquatic chronic category 2 as per the CLP classification criteria.
Short term toxicity on aquatic invertebrates
Using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances, the short term toxicity on aquatic invertebrates was predicted for 1,1-diethoxy-3,7-dimethylocta-2,6-diene (7492-66-2). EC50 value was estimated to be 12.5 mg/l for Daphnia magna for 48 hrs duration. Based on the value, 1,1-diethoxy-3,7-dimethylocta-2,6-diene (7492-66-2) was considered to be toxic to aquatic invertebrates, hence it can be considered to be classified in chronic category 3 as per the CLP regulations.
Toxicity to aquatic algae and cyanobacteria
Predicted data for the target chemical 1,1-diethoxy-3,7-dimethylocta-2,6-diene(CAS No. 7492-66-2) and various weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed to summarize the following information:
Short term toxicity on aquatic algae and cyanobacteria of target chemical1,1-diethoxy-3,7-dimethylocta-2,6-diene(CAS No. 7492-66-2) is predicted using the OECD QSAR toolbox version 3.3 with log kow as the primary descriptor and considering the five closest read across substances (2017).EC50 value was estimated to be 4.89 mg/l for Desmodesmus subspicatus for 72 h duration. Based on this value it can be concluded that the substance 1,1 -diethoxy-3,7 -dimethylocta-2,6 -diene is considered to be toxic to aquatic environment and can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.
In a weight of evidencestudy from secondary source (HPVIS, 2016) of the read across chemical 11 -methyldodecan-1 -ol (CAS no. 68526 -86 -3),short term toxicity to Pseudokirchnerella subcapitata (green algae) study was carried out for 72 hrs. The study was performed according to OECD Guideline 201 (Alga, Growth Inhibition Test). The study was based on the effects of the read across compound 11 -methyldodecan-1 -ol (CAS no. 68526 -86 -3) on Pseudokirchnerella subcapitata in a static fresh water system under a continuous illumination with a light intensity of 7600 to 7800 Lux., at a temperature of 23.1°C, pH ranges from 6.8 to 7.4 respectively. Pseudokirchnerella subcapitata was used as a test organism. Test chemical concentration used for the study was0,1.5, 3.0, 8.0, 20 and 61mg/L (nominal concentration) and1.5, 2.2, 2.2, 2.5, 3.0 mg/l (measured concentration), respectively. Individual Water Accomodated Fractions (WAFs) were prepared for each test treatment. The test substance was added volumetrically, via a syringe, to 2L of dilution water in a 2L glass bottle. The solution was mixed for 23 hours at a vortex of 8% of the total depth. Mixing temperature was approximately 23 Deg C. After a 1 hour settling/cooling period, the aqueous portions were transferred to the test chambers via the port at the bottom of the mixing vessel and used for testing. Test vessels were 125 ml glass Erlenmeyer flasks that were filled with approximately 60 ml of treatment solution and inoculated with algae. Samples were taken daily for cell counts. Four replicates were prepared for each treatment level. The initial algal concentration was 1.0 x 104cells/ml. All test replicates were placed on a shaker table at 100 oscillations per minute during the study. Biomass was calculated as the area under the growth curve. Based on effect on growth rate of the test organism Pseudokirchnerella subcapitata, the 72 hr NOEC and EC50 value was determined to be 2.2 and 3.2 mg/l and on the basis of effect on biomass, the 72 hr NOEC and EC50 value was determined to be 1.5 and 2.6 mg/l, respectively. Thus, based on the EC50 value, it can be concluded that the substance 11 -methyldodecan-1 -ol can be considered as toxic to aquatic organisms and thus can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.
Another short term toxicity to algae study was carried out for 72 hrs (OECD SIDS, 2006). The study was based on the effects of the read across compound 7 -methyloctan-1 -ol (CAS no. 27458-94-2) on algae in a static fresh water system. After 72 hours of exposure to 7 -methyloctan-1 -ol, the EC50 value was determined to be ranges from 1.6 to 19.0 mg/l. Thus, based on the EC50 value (1.6 mg/l), it can be concluded that the substance 7 -methyloctan-1 -ol can be considered as toxic to algae at environmentally relevant concentrations and can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.
Thus, based on the overall reported results for target chemical1,1-diethoxy-3,7-dimethylocta-2,6-diene(OECD QSAR toolbox version 3.3, 2017) and for its read across substance (fromsecondary source HPVIS and OECD SIDS),it can be concluded that the test substance 1,1 -diethoxy-3,7 -dimethylocta-2,6 -diene can be considered as toxic to aquatic environment and can be considered to be classified in aquatic chronic category 2 as per the CLP classification criteria.
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