Registration Dossier
Registration Dossier
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EC number: 615-749-4 | CAS number: 72291-30-6
Endpoint summary
Administrative data
Description of key information
2 -Cyano-2 -methyl-propanoic acid-methyl ester was tested for acute oral toxicity in rats according to OECD Guideline 423. The median lethal dose of 2-Cyano-2-methyl-propanoic acid-methyl ester after oral administration was found to be greater than 2000 mg/kg body weight in female Wistar rats.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity:
The test item 2 -Cyano-2 -methyl-propanoic acid-methyl ester was tested for acute oral toxicity in rats according to OECD Guideline 423. The substance was administerd by oral gavage as an emulsion in olive oil in a dose of 300 mg/kg bw to 3 female Wistar rats. No death occurred in this dose range. The test item was administered in a further dose of 2000 mg/kg bw to additional 6 female Wistar rats. No death occurred in this dose group. No mortality occurred during the observation period. No clinical observations were observed. No macroscopic pathologic abnormalities were noted in the animals examined at termination of the study.
Under the conditions of this study the median lethal dose of 2-Cyano-2-methyl-propanoic acid-methyl ester after oral administration was found to be greater than 2000 mg/kg body weight in rats (BASF, 2005).
Justification for classification or non-classification
No classification and labelling for acute oral toxicity is required according to Directive 67/548/EEC (DSD) or Regulation (EC) No 1272/2008 (GHS(EU-CLP)) criteria.
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