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EC number: 213-384-1 | CAS number: 941-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from NTRL report
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Basic toxicity of 1-acetonaphthalene in rats and mice with cover letter dated 06/10/92
- Author:
- D. C. Topping
- Year:
- 1 992
- Bibliographic source:
- NTRL OTS0537531, Updated at June 10 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Repeated dose dermal toxicity study was performed to determine the dermal toxic nature of 1- Acetonaphthalene
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 1'-acetonaphthone
- EC Number:
- 213-384-1
- EC Name:
- 1'-acetonaphthone
- Cas Number:
- 941-98-0
- Molecular formula:
- C12H10O
- IUPAC Name:
- 1'-acetonaphthone
- Details on test material:
- - Name of test material: 1- Acetonaphthalene
- Molecular formula: C12H10O
- Molecular weight: 170.21 g/mol
- Substance type: Organic
- Physical state: No data
- Impurities (identity and concentrations): No data
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Details on species / strain selection:
- No data
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- not specified
- Details on exposure:
- TEST SITE
- Area of exposure: Clipped backs
- % coverage: No data
- Type of wrap if used: No data
- Time intervals for shavings or clipplings: No data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): No data
- Constant volume or concentration used: No data
- For solids, paste formed: No data
VEHICLE
- Justification for use and choice of vehicle (if other than water): No data
- Amount(s) applied (volume or weight with unit): No data
- Concentration (if solution): No data
- Lot/batch no. (if required): No data
- Purity: No data
USE OF RESTRAINERS FOR PREVENTING INGESTION: No data - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data
- Duration of treatment / exposure:
- 10 days
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- 0.5mL (557.2 mg/kg)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- No data
- Positive control:
- No data
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: No data
- Time schedule: No data
- Cage side observations checked in table [No.?] were included. No data
DETAILED CLINICAL OBSERVATIONS: Yes
- Time schedule: No data
DERMAL IRRITATION (if dermal study): Yes
- Time schedule for examinations: No data
BODY WEIGHT: No data
- Time schedule for examinations: No data
FOOD CONSUMPTION:
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No data
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No data
WATER CONSUMPTION: No data
- Time schedule for examinations: No data
OPHTHALMOSCOPIC EXAMINATION: No data
- Time schedule for examinations: No data
- Dose groups that were examined: No data
HAEMATOLOGY: No data
- Time schedule for collection of blood: No data
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals: No data
- Parameters checked in table [No.?] were examined. No data
CLINICAL CHEMISTRY: No data
- Time schedule for collection of blood: No data
- Animals fasted: No data
- How many animals: No data
- Parameters checked in table [No.?] were examined. No data
URINALYSIS: No data
- Time schedule for collection of urine: No data
- Metabolism cages used for collection of urine: No data - Animals fasted: No data - Parameters checked in table [No.?] were examined. No data
NEUROBEHAVIOURAL EXAMINATION: No data
- Time schedule for examinations: No data
- Dose groups that were examined: No data
- Battery of functions tested: sensory activity / grip strength / motor activity / other: No data
OTHER: No data - Sacrifice and pathology:
- GROSS PATHOLOGY: No data
HISTOPATHOLOGY: No data - Other examinations:
- No data
- Statistics:
- No data
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- not specified
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Neuropathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
- Details on results:
- Clinical signs and mortality
Clinical signs: Slight exacerbation was noted upon repeated application
Mortality: No data
Dermal irritation: Slight erythema was noted in 4/5 guinea pigs on day 1 and slight to moderate erythema in 5/5 and edema and/or vesicles in 4/5 guinea pigs after 2 weeks.
Body weight and weight gain: No data
Food consumption and compound intake: No data
Food efficiency: No data
Water consumption and compound intake: No data
Opthalmoscopic examination: No data
Haematology: No data
Clinical chemistry: No data
Urinanalysis: No data
Neurobehaviour: No data
Organ weights: No data
Gross pathology: No data
Histopathology: No data
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 557.2 other: mg/Kg
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Slight exacerbation, erythema and edema formation was observed
- Remarks on result:
- other: No toxic effects were observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The No Observed Adverse Effect level (NOAEL) for test chemical was considered to be 0.5mL (557.2 mg/kg) when applied to the clipped backs of guinea pigs.
- Executive summary:
Repeated dose dermal toxicity study was performed to determine the dermal toxic nature of test chemical . Uncovered application of 0.5mL (557.2 mg/kg) of the test compound was applied daily for 10 days to the clipped backs of 5 guinea pigs. The animals were observed for dermal irritation. Slight exacerbation was noted upon repeated application. Slight erythema was noted in 4/5 guinea pigs on day 1 and slight to moderate erythema in 5/5 and edema and/or vesicles in 4/5 guinea pigs after 2 weeks. However, the report mentions no percutaneous absorption at 20mL/Kg dose (22288 mg/Kg bw/day) in acute dermal toxicity study performed. Since the no percuteaneous absorption acute dermal dose of 22288 mg/Kg bw/day is greater than the repeated dose dermal toxicity dose (557.2 mg/Kg bw) and hence on this basis, the No Observed Adverse Effect level (NOAEL) for 1- Acetonaphthalene is considered to be 0.5mL (557.2 mg/kg) when applied to the clipped backs of guinea pigs.
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