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Diss Factsheets
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EC number: 425-270-0 | CAS number: 134620-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 April 2008
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study, to GLP. Limited reporting detail.
- Qualifier:
- according to guideline
- Guideline:
- other: Particle size distribution, fibre length and diameter distribution. June 1996 European Commission technical guidance document
- Deviations:
- not specified
- Remarks:
- Guideline not available for consultation and comparison. However, reporting detail is limited (e.g. missing information on purity)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- cascade impaction
- Type of distribution:
- mass based distribution
- Percentile:
- D50
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
- No.:
- #1
- Size:
- < 45 µm
- Distribution:
- 96 %
- No.:
- #2
- Size:
- < 10 µm
- Distribution:
- 13.4 %
- Conclusions:
- In a guideline study, conducted to GLP, the particle size distribution of tetraamminepalladium(II) hydrogen carbonate was determined by mass difference following cascade impaction. 13.4% of the pre-sieved (< 45 um) particles had a size < 10 um, and could be expected to achieve alveolar deposition in man, if inhaled. Approximately 96% of the pre-sieved particles were sufficiently small to reach at least the tracheo-bronchial region of the respiratory tract.
- Executive summary:
In a guideline study, conducted to GLP, the particle size distribution of tetrammine palladium hydrogen carbonate was determined by mass difference following cascade impaction. 13.4% of the pre-sieved (< 45 um) particles had a size < 10 um, and could be expected to achieve alveolar deposition in man, if inhaled. Approximately 96% of the pre-sieved particles were sufficiently small (< 45 um) to reach at least the tracheo-bronchial region of the respiratory tract.
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 21 February 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Only a 1 page study summary, though the critical information for this endpoint is included.
- Qualifier:
- according to guideline
- Guideline:
- ISO 13320 (Particle size analysis - Laser diffraction methods)
- Deviations:
- not specified
- GLP compliance:
- yes
- Other quality assurance:
- other: no data
- Type of method:
- Laser scattering/diffraction
- Type of particle tested:
- other: no data
- Type of distribution:
- volumetric distribution
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 1212/14-A6
- Expiration date of the lot/batch: No data
- Purity test date: No data
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: No data
- Stability under test conditions: No data
- Solubility and stability of the test substance in the solvent/vehicle: No data
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No data
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: No data
- Final dilution of a dissolved solid, stock liquid or gel: No data
- Final preparation of a solid: No data - Percentile:
- D10
- Mean:
- 23 µm
- Remarks on result:
- other: average of three measurements
- Percentile:
- D50
- Mean:
- 82 µm
- Remarks on result:
- other: average of three measurements
- Percentile:
- D90
- Mean:
- 154 µm
- Remarks on result:
- other: average of three measurements
- Conclusions:
- In a particle size distribution study with tetraamminepalladium(II) hydrogen carbonate, respective d10, d50 and d90 values of 23, 82 and 154 μm were measured.
- Executive summary:
In a guideline (ISO 13320) particle size distribution study with tetraamminepalladium(II) hydrogen carbonate, respective d10, d50 and d90 values of 23, 82 and 154 μm were measured using laser diffraction.
Referenceopen allclose all
The results indicate that approximately 13.4% of the particles were of a size which could be expected to achieve alveolar deposition in man, if inhaled. Approximately 96% of the particles were sufficiently small to reach at least the tracheo-bronchial region of the respiratory tract [although it should be noted that the sample was sieved prior to analysis, removing most of the particles > 45 um].
Description of key information
In a guideline study, conducted to GLP, the particle size distribution of tetraamminepalladium(II) hydrogen carbonate was determined by mass difference following cascade impaction. 13.4% of the pre-sieved (< 45 um) particles had a size < 10 um, and could be expected to achieve alveolar deposition in man, if inhaled. Approximately 96% of the pre-sieved particles were sufficiently small (< 45 um) to reach at least the tracheo-bronchial region of the respiratory tract (Mulle and Bartlett, 1997).
In a guideline (ISO 13320) particle size distribution study with tetraamminepalladium(II) hydrogen carbonate, respective d10, d50 and d90 values of 23, 82 and 154 μm were measured using laser diffraction.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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