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EC number: 203-166-4 | CAS number: 104-01-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from NTIS study report.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Summary of toxicity studies for 4-METHOXYPHENYLACETIC ACID (MPAA)
- Author:
- National Technical Information Service
- Year:
- 1 991
- Bibliographic source:
- National Technical Information Service, OTS0530656-1 (1991)
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Skin irritation study was carried out to test the effects of 4 methoxy phenylacetic acid (MPAA) on New Zealand rabbits at concentration of 0.5gms.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-methoxyphenylacetic acid
- EC Number:
- 203-166-4
- EC Name:
- 4-methoxyphenylacetic acid
- Cas Number:
- 104-01-8
- Molecular formula:
- C9H10O3
- IUPAC Name:
- 2-(4-methoxyphenyl)acetic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report):4 methoxy phenylacetic acid (MPAA)
- Molecular formula : C9H10O3
- Molecular weight : 166.175g/mol
- Smiles notation: c1(ccc(OC)cc1)CC(O)=O
- InChl : 1S/C9H10O3/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H, 6H2, 1H3, (H,10,11)
- Substance type: Organic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):4 methoxy phenylacetic acid (MPAA)
- Molecular formula : C9H10O3
- Molecular weight : 166.175g/mol
- Smiles notation: c1(ccc(OC)cc1)CC(O)=O
- InChl : 1S/C9H10O3/c1-12-8-4-2-7(3-5-8)6-9(10)11/h2-5H, 6H2, 1H3, (H,10,11)
- Substance type: Organic
- Physical state: Solid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- other: Gauze patch and adhesive tape
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 0.5gms
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1 hrs after removal of cover and 1,2,3 days after removal
- Number of animals:
- 6 animals
- Details on study design:
- TEST SITE
- Area of exposure: 6 square cms of clipped skin
- Type of wrap if used: Gauze patch
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Skin wiped free of excess test material with absorbant pad
- Time after start of exposure: 4 hours
SCORING SYSTEM: Draize scoring system approx 1 hr after removal of cover and 1,2 3 days after removal.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: maximum mean dermal irritation score
- Basis:
- mean
- Time point:
- other: 1 hr,1,2 and 3 days
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- not irritating to skin of rabbits
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- 4 methoxy phenylacetic acid (MPAA) was considered to be not irritating under test conditions of this study.
- Executive summary:
A skin irritation study was carried out to test the effects of 4 methoxyphenyl acetic acid on New Zealand rabbits. Six New Zealad White rabbits were treated with 0.5 gm of test substance moistened with water.The Area of exposure was 6 square cm of clipped skin and the wrap used was Gauze patch. The cover was removed after 4 hours of exposure and the skin was wiped free of excess test material with absorbant pad.The skin reactions in the rabbits were observed and evaluated according to Draize method after 1 hr of removal of cover and 1, 2,3 days after removal . The minimum mean dermal irritation score at any observation was 0.0 (Maximum possible score is 8.0). No animal showed any indication of dermal irritation.
Thus, it was considered that 4 methoxy phenylacetic acid (MPAA) was not irritating to skin.
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