4-trans-propenylveratrole

Auto flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

auto-ignition temperature (liquids)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 January - 20 October, 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

The study was conducted according to an internationally recognised method, and under GLP. No deviation was reported. Test substance is adequately specified with purity. Therefore full validation applies.

Qualifier:

according to guideline

Guideline:

EU Method A.15 (Auto-Ignition Temperature (Liquids and Gases))

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: BS 4056

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Remarks:

UK GLP compliance programme (inspected on 05 February 2014 / signed on 07 October 2015)

Key result

Auto-ignition temperature:

374 °C

Atm. press.:

1 024 mBar

Table 4.12/1: Auto flammability – results

Test temperature (°C)	Test volume (µL)	Time (s)	Observation
400	70	2	Yellow flame
350	70	>300	White smoke, no ignition
350	1000	>300	White smoke, no ignition
376	70	2	Yellow flame
362	70	>300	White smoke, no ignition
362	1000	>300	White smoke, no ignition
368	70	>300	White smoke, no ignition
368	1000	>300	White smoke, no ignition
372	70	>300	White smoke, no ignition
372	1000	>300	White smoke, no ignition
374	70	4	Yellow flame
372	100	>300	White smoke, no ignition
372	200	>300	White smoke, no ignition
372	500	>300	White smoke, no ignition
372	70	>300	White smoke, no ignition
372	70	>300	White smoke, no ignition
372	70	>300	White smoke, no ignition
372	70	>300	White smoke, no ignition
372	70	>300	White smoke, no ignition

Atmospheric pressure: 1024 mbar

Conclusions:

The auto-ignition temperature of the test substance has been determined to be 374 °C.
This parameter/method is not relevant for classification, however the information is useful regarding potential additional fire hazard.
No particular hazard is anticipated in normal conditions of storage.

Executive summary:

The auto-ignition temperature of the test substance was measured under GLP according to BS 4056 standard (listed in EU A.15 guideline). Test substance was injected into a heated flask, and the lowest flask temperature at which ignition occurred was taken as the auto-ignition temperature.

The auto-ignition temperature of the test substance has been determined to be 374 °C.

Reference 2

Endpoint:

auto-ignition temperature (liquids)

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The hypothesis is based on structural similarity, and on compared flash points.
Both source (tested) and target substances consist of a methyl ether benzene ring. The source substance is also substituted with an hydroxyl group (ortho position to the ether) and a propyl group (para position to the hydroxyl); in the target substance, a second methyl ether group is positioned ortho to the first one, and a propylene is in para position.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Refer to the Test material section of the source and target records.

3. ANALOGUE APPROACH JUSTIFICATION
Both substances are not expected to have significantly different AIT, and the read-across is considered suitable. Moreover, the analogue has a similar Flash Point, which supports the extrapolation of AIT

4. DATA MATRIX
Source 2-Methoxy-4-propylphenol FP = 114°C (Envigo 2015, same report as AIT)
Target (E)-2-Methoxy-4-prop-1-en-1-ylphenol FP = 118°C (Envigo 2015; please refer to IU section 4.11)

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across: supporting information

Key result

Auto-ignition temperature:

ca. 374 °C

Atm. press.:

1 024 mBar

Conclusions:

(from analogue) The auto-ignition temperature of the target substance is expected to be ca 374 °C.
This parameter/method is not relevant for classification, however the information is useful regarding potential additional fire hazard.
No particular hazard is anticipated in normal conditions of storage.

Executive summary:

The auto-ignition temperature of the test substance was measured under GLP according to BS 4056 standard (as listed in EU A.15 guideline). Test substance was injected into a heated flask, and the lowest flask temperature at which ignition occurred was taken as the auto-ignition temperature.

The auto-ignition temperature of the test substance has been determined to be 374 °C. Read-across is justified as the target substance is structurally similar (methyl ether instead of hydroxyl substituent, and one double bond more in propyl/propylene substituent), as well as both flash points.

Description of key information

(from analogue) AIT expected ca 374°C

Key value for chemical safety assessment

Autoflammability / Self-ignition temperature at 101 325 Pa:

374 °C

Additional information

No data is available on the substance itself. However, a reliable experimental study, conducted according to a recognized EC/BS method and under GLP, is available on an analogue.

Based on chemical similarity, and compared flash points, no significant difference is anticipated with the present dossier substance, so the read-across is considered justified for a key study.

This parameter is not relevant for classification, however the information is useful regarding process safety and potential additional fire hazard.

No particular hazard is anticipated in normal conditions of storage.