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EC number: 207-321-7 | CAS number: 462-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
- Reference Type:
- other: letter
- Title:
- Letter from E.I. du Pont de Nemours & Co Inc to US EPA regarding submission of studies using p-Fluorotoluene with attachments
- Author:
- TSCATS
- Year:
- 1 990
- Bibliographic source:
- Doc ID FYI-DTS-1090-0792, Microfiche No. OTS0000792
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Groups of 6 male Crl:CD BR rats were exposed to vapor atmospheres of fluorobenze for a single 4-hour period.
- GLP compliance:
- yes
- Test type:
- other: Inhalation Approximate Lethal Concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Fluorobenzene
- EC Number:
- 207-321-7
- EC Name:
- Fluorobenzene
- Cas Number:
- 462-06-6
- Molecular formula:
- C6H5F
- IUPAC Name:
- fluorobenzene
- Details on test material:
- - Name of test material (as cited in study report): Fluorobenzene
- CAS No.: 462-06-6
- Physical form: colourless liquid
- Purity: > 99%
- Supplier: Aldrich Chemical Co. Catalog No. F600-1
- Stability: The TS was assumed to be stable throughout the exposure phase of the test
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD BR
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Kingston, New York
- Age at study initiation: 8 weeks
- Weight at study initiation: 229-269 g
- Housing: single housing in suspended, stainless steel, wire-mesh cages; during the test, rats were housed in pairs.
- Diet: Purina Certified Rodent Chow #5002 ad libitum (except during exposure)
- Water: ad libitum (except during exposure)
- Acclimation period: rats were quarantined for one week upon receipt; afterwards, they were held in stock for up to one week prior to testing
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- other: air
- Details on inhalation exposure:
- EXPOSURE PROTOCOL:
For each exposure, 6 rats were individually restrained in perforated, stainless steel cylinders with conical nose pieces. The restrainers were inserted into a face plate on the exposure chamber such that only-the nose of each rat protruded into the chamber. Each group of 6 rats was exposed nose-only for 4 continuous hours to a vapor atmosphere of fluorobenzene in air.
ATMOSPHERE GENERATION:
Vapor atmospheres of fluorobenzene were generated by pumping the liquid test material with a Harvard Model 975 Compact Infusion Pump into a 3-neck glass mixing flask. The flask was heated to 84-93°C with a Briskeat Model BC-170 heater to facilitate evaporation. The flask temperature was controlled with a Teco Model TC-1000 controller and was monitored with an Omega Type K Thermocouple Thermometer. Air introduced at the flask (approximately 22 L/min) swept the fluorobenzene vapors through a glass dispersion funnel and into the exposure chamber. Additional dilution air (approximately 1-18 L/min depending on desired concentration) was added to the vapor mixture prior to its entry into the chamber. The chamber exhaust was drawn through a dry ice cold trap and a MSA cartridge filter prior to being vented into the hood. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- by gas chromatography approx. every 30 min during exposure
- Duration of exposure:
- 4 h
- Concentrations:
- 50, 520, 3700, 6200 and 10000 ppm
- No. of animals per sex per dose:
- 6 males per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Rats were weighed and observed prior to exposure. Group observations of clinical signs of toxicity were taken during each exposure and when rats were released from restrainers after exposure. Surviving rats were weighed and observed daily for 14 days post exposure, weekends and holidays included when warranted by the rats' condition.
- Necropsy of survivors performed: no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- other: Approximate Lethal Concentration
- Effect level:
- 6 200 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: equivalent to 24.7 mg/L
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 6 200 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: equivalent to 24.7 mg/L
- Mortality:
- Two of 6 rats exposed to 6200 ppm and 5 of 6 rats exposed to 10,000 ppm died during exposure.
- Clinical signs:
- other: Please see any other information for description.
- Body weight:
- During the postexposure period, no significant weight loss or adverse clinical signs were observed in rats that survived exposure to fluorobenzene. No adverse clinical signs and average weight losses of 2% or less of initial body weight were observed in rats exposed to 50, 520 or 6200 ppm. Rats exposed to 3700 ppm were not weighed and observed one day after exposure. However, 3 of 6 rats had lost an average of 3% of initial body weight on the 2nd day post exposure, and no adverse clinical signs were observed. The one rat that survived exposure to 10,000 ppm had a dry red ocular discharge and lost 5% of initial body weight one day after exposure.
Any other information on results incl. tables
Concentration of fluorobenzene vapour atmospheres and rat mortality:
Concentration (ppm) | Mortality (# deaths/# exposed) | ||
Mean | SD | Range | |
50 | 8.3 | 40-61 | 0/6 |
520 | 17 | 500-550 | 0/6 |
3700 | 1100 | 2000-6000 | 0/6 |
6200 | 630 | 5400-7400 | 2/6 |
10000 | 740 | 8800-11000 | 5/6 |
CLINICAL SIGNS
During or immediately following exposure, rats exposed to 50, 520 or 6200 ppm had red nasal or ocular discharges, effects common to rats under restraint. Rats exposed to 10,000 ppm had no response to sound during exposure. When released from restrainers after exposure, rats exposed to 3700 ppm and rats that survived exposure to 6200 or 10,000 ppm had rapid breathing, tremors, spasms, no righting reflex and clear oculardischarge.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The ALC for fluorobenzene was 6200 ppm (equally to 24.7 mg/L). The TS is considered to have very low toxicity on an acute inhalation basis (ALC > 5000 ppm).
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