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EC number: 944-533-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 November 2016 and 29 November 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. Restrictions apply considering the complex nature of the substance and the interpretation of the result. The substance is considered to be adequately characterised. Therefore validation with restrictions applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- 2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 2009
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected on 1,2 and 3 July 2014 / signed on 5 Mars 2015
- Type of method:
- static method
- Temp.:
- 20 °C
- Vapour pressure:
- 1 183 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 1 504 Pa
- Executive summary:
The vapour pressure of the test item was measured under GLP using the static method as described in EU method A.4 and OECD 104.
Two trials were conducted and five points were recorded for each trial in a temperature range of 19.0 – 37.2 °C. The pairs of Temperature / Vapour pressure were used to calculate a regression from which vapour pressure at ambient temperature can be interpolated.
Finally, the vapour pressure of the test item was calculated as 1183 Pa at 20°C and 1504 Pa at 25°C.
Note that the result obtained on this kind of substance should be largely influence by small amounts of volatile constituents and these values don't represent the major part of the substance. Therefore the result should be considered with caution when used for subsequent assessment (worst case).
Reference
First trial
Vapour Pressure (Pa) |
Time (hh:mn) |
Corresponding Temperature (°C) |
Temperature (K) |
1/T (K-1) |
Log10(p) |
1220 |
09:50 |
19.3 |
292.45 |
3.419E-03 |
3.086 |
1502 |
11:00 |
23.8 |
296.95 |
3.368E-03 |
3.177 |
1890 |
12:10 |
28.2 |
301.35 |
3.318E-03 |
3.276 |
2302 |
13:45 |
32.9 |
306.05 |
3.267E-03 |
3.362 |
2690 |
15:05 |
37.2 |
310.35 |
3.222E-03 |
3.430 |
A plot of Log10(p) versus reciprocal temperature (1/T) (with p in Pa and T in K) gave the following statistical data using an unweighted least square treatment.
Slope -1764.9
Intercept 9.1239
R² 0.9976
The results obtained indicated the following vapour pressure relationship:
Log10(p (Pa)) = -1764.9 / T (K) +9.1239
The above equation yielded a vapour pressure of 1269 Pa at 293.15 K and 1601 Pa at 298.15 K.
Second trial
Vapour Pressure (Pa) |
Time (hh:mn) |
Corresponding Temperature (°C) |
Temperature (K) |
1/T (K-1) |
Log10(p) |
1020 |
10:40 |
19.0 |
292.15 |
3.423E-03 |
3.009 |
1340 |
11:45 |
23.6 |
296.75 |
3.370E-03 |
3.127 |
1660 |
13:40 |
28.2 |
301.35 |
3.318E-03 |
3.220 |
2063 |
15:10 |
32.8 |
305.95 |
3.269E-03 |
3.314 |
2441 |
16:35 |
37.1 |
310.25 |
3.223E-03 |
3.388 |
A plot of Log10(p) versus reciprocal temperature (1/T) (with p in Pa and T in K) gave the following statistical data using an unweighted least square treatment.
Slope -1890.7
Intercept 9.4898
R² 0.9970
The results obtained indicated the following vapour pressure relationship:
Log10(p (Pa)) = -1890.7 / T(K) + 9.4898
The above equation yielded a vapour pressure of 1097 Pa at 293.15 K and 1407 Pa at 298.15 K.
Summary of Results
Trial |
Vapour pressure at 293.15 K |
Vapour pressure at 298.15 K |
1 |
1269 Pa |
1601 Pa |
2 |
1097 Pa |
1407 Pa |
Mean |
1183 Pa |
1504 Pa |
For the two determinations, the test item did not change in appearance since its first heating at 40°C. However, it may be noted traces of bubbles at the surface of the test item.
Discussion
Five pairs temperature/pressure were used to define a linear regression, from which vapour pressure at 20°C and 25°C could be estimated. The test was performed in duplicate.
The study is conducted in a closed system and the protocol was established in taking into account the complex nature of the substance.
- The measurement range was limited to remain in a linearity range.
- The tested temperatures were similar to temperatures currently used in the handling of the substance.Therefore no significant chemical reactions should be considered in the experimental conditions;
- We take care to obtain an homogenous mass and to allow any bubbles in the sample to come to the surface prior measurement and measurements are below 40°C. Therefore no impact of residual air was anticipated and
- We take care to minimally alter the composition of the complex substance, i.e. to consider the most volatile constituents as part of the composition of the UVCB substance in the measurements.
Finally, the correlation factor of the regression equations for log10(p)=f(1/T) was over 0.95 for the both trials (0.9976 for the first trial and 0.997 for the second trial).
The difference between the two trials was less than 20% (14.5% at 20°C and 12.9%at 25°C).
Therefore, the results of this study were considered valid.
Description of key information
The vapour pressure of the test item was calculated as 1 183 Pa at 20°C and 1 504 Pa at 25°C (interpolation)
Note that the result obtained on this kind of substance should be largely influence by small amounts of volatile constituents and these values don't represent the major part of the substance. Therefore the result should be considered with caution when used for subsequent assessment (worst case).
Key value for chemical safety assessment
- Vapour pressure:
- 1 504 Pa
- at the temperature of:
- 25 °C
Additional information
A reliable experimental study conducted according to a recognized OECD/EC method and under GLP, is available.
Therefore it is considered as a key study and the result is retained as key data.
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