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EC number: 259-943-3 | CAS number: 56011-02-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 March to 5 April 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Isopentyl phenethyl ether
- EC Number:
- 259-943-3
- EC Name:
- Isopentyl phenethyl ether
- Cas Number:
- 56011-02-0
- Molecular formula:
- C13H20O
- IUPAC Name:
- isopentyl phenethyl ether
Constituent 1
- Specific details on test material used for the study:
- Test material name (as stated in the report): ANTHER
Appearance: Colourless liquid
Batch S12 884 T5
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- S-9 liver
- Test concentrations with justification for top dose:
- based on the dose range finding test:
(1) 500, 150, 50, 15 and 5 microg/plate
(2) 10, 5, 2.5 microg/plate - Vehicle / solvent:
- Solvent: Dimethylsulphoxide
Controlsopen allclose all
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- no
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 2-nitrofluorene
- Remarks:
- 10 microg/plate for strains TA1538 and TA 98
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- no
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- 9-aminoacridine
- Remarks:
- 20 microg/plate for strains TA1537
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- no
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: sodium azide
- Remarks:
- 5 microg/plate for strains TA1535 and TA100
Results and discussion
Test results
- Key result
- Species / strain:
- other: TA1535, TA1537. TA1538, TA98 and TA100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- Anther was toxic in all strain at the top dose 5000 microg/plate in the dose range finding test
- Positive controls validity:
- valid
Any other information on results incl. tables
Anther was toxic towards all of the strains at the 5000 microg/plate dose levels. Therefore the 500 microg/plate was chosen as the top dose level in the mutation test.
A slight increase in revertant colony numbers was observed with the tester strain TA98 at the lower dose levels in the presence of s9mix. No substantial increase in revertant colony numbers was observed in the repat test indicating that the original increase was spurious. No substantial increase in the revertant colony numbers of any of the remaining four strains were observed following treatment with Anther at any dose level, either in presence or absence of liver microsomal fraction (s9mix).
Applicant's summary and conclusion
- Conclusions:
- It is concluded that no evidence of mutagenic potential of Anther was obtained in this bacterial test system at the dose levels used.
- Executive summary:
The Anther was examined for mutagenic potential in this Ames metabolic activation test to assess the potential mutagenic effect dated on 28 May 1982, performed at Huntington Laboratory.
Anther was toxic towards all of the strains at the 5000 microg/plate dose levels. Therefore the 500 microg/plate was chosen as the top dose level in the mutation test.
A slight increase in revertant colony numbers was observed with the tester strain TA98 at the lower dose levels in the presence of s9mix. No substantial increase in revertant colony numbers was observed in the repat test indicating that the original increase was spurious. No substantial increase in the revertant colony numbers of any of the remaining four strains were observed following treatment with Anther at any dose level, either in presence or absence of liver microsomal fraction (s9mix). It is concluded that no evidence of mutagenic potential of Anther was obtained in this bacterial test system at the dose levels used.
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