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EC number: 237-502-6 | CAS number: 13820-53-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 3 days; no data on actual dates
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Conducted according to US CFR (1973) guidelines, pre-GLP, but scientifically acceptable
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Federal register Vol. 38, No. 187, section 1500:41 (1973)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- Reference substance 002
- Cas Number:
- 13820-53-6
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): sodium chloropalladite
- Substance type: brown powder
- Physical state: solid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Purity test date: no data
- Lot/batch No.: 041118/A
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: supplied in closed glass jar; no further details
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: “recognised breeder”
- Age at study initiation: 14-16 weeks
- Weight at study initiation: mean 2.2 kg
- Housing: no data
- Diet (e.g. ad libitum): conventional; ad libitum
- Water (e.g. ad libitum): filtered water; ad libitum
- Acclimation period: no details
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): natural lighting
report states “environmentally controlled room”
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: shaved and (on one side) abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: no concurrent control site
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 mg (no data if applied as the powder or made into a paste) - Duration of treatment / exposure:
- 24 hr
- Observation period:
- 24 and 72 hr
- Number of animals:
- 6 females
- Details on study design:
- TEST SITE
- Area of exposure: 6.25 cm2 each of shaved dorsal skin and shaved and abraded dorsal skin
- % coverage: about 5% each intact and abraded
- Type of wrap if used: gauze pad, secured by adhesive tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no removal of test substance
- Time after start of exposure:
SCORING SYSTEM: assessed for primary irritation index at 24 and 72 hr using the Draize method of scoring. Scores for erythema/eschar formation and edema for both intact and abraded skin at both time points were totalled and divided by 24 to give the primary irritation index.
Primary irritation index Classification
0 non-irritant
> 0-2 mild irritant
> 2-5 moderate irritant
> 5-8 severe irritant
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: Mean of 24 and 72 hr time points
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not relevant
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: Mean of 24 and 72 hr time points
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not relevant
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: Mean of 24 and 72 hr time points
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not relevant
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No irritant effects were observed; no indication that corrosivity was assessed
- Other effects:
- No indication that systemic effects were assessed
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No irritation was observed following a 24-hr semi-occluded application of disodium tetrachloropalladate (500 mg) to the intact or abraded skin of six rabbits.
- Executive summary:
In an early pre-GLP study, conducted according to US CFR guidelines, the irritant potential of disodium tetrachloropalladate, available as a brown powder, was assessed on the shaved intact and abraded skin of six New Zealand white rabbits.
In a 24 hr semi-occluded patch test, 500 mg of the test substance did not cause any irritation to either intact or abraded skin when assessed immediately on removal of the patch and 48 hr later. Residual test material was not washed off the skin during this period. As such, no classification for skin irritancy is required according to EU CLP criteria (EC 1272/2008).
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