Registration Dossier
Registration Dossier
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EC number: 204-255-0 | CAS number: 118-48-9
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- The cytotoxic activity of cyclic imido alkyl ethers, thioethers, sulfoxides, sulfones and related derivatives.
- Author:
- Hall IH et al.
- Year:
- 1 994
- Bibliographic source:
- Anti-cancer drugs 5: 75-82.
Materials and methods
- Type of study / information:
- cytotoxicity
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4H-3,1-benzoxazine-2,4(1H)-dione
- EC Number:
- 204-255-0
- EC Name:
- 4H-3,1-benzoxazine-2,4(1H)-dione
- Cas Number:
- 118-48-9
- Molecular formula:
- C8H5NO3
- IUPAC Name:
- 4H-3,1-benzoxazine-2,4(1H)-dione
- Details on test material:
- Isatoic anhydride; no further data
Constituent 1
Results and discussion
Any other information on results incl. tables
The test substance inhibited growth of L1210 lymphoid leukemia, human Tmolt3 leukemia, and brain glioma.
Table: ED 50 values of Isatoic anhydride for the different cell lines:
| Cell line | cell type | ED50 [µg/mL) |
| L1210 | murine | 2.01 |
| Tmolt3 | human | 4.51 |
| SW 48 colon adenocarcinoma | human | 4.12 |
| HeLa S3 | human | 1.60 |
| KB nasopahrynx | human | 7.31 |
| Bronchogenic lung | human | 7.57 |
| osteosarcoma | human | 2.78 |
| brain glioma | human | 1.94 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
