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EC number: 230-291-1 | CAS number: 7011-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1984-09-25 to 1984-10-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Principles of method if other than guideline:
- The deviation was that the test substance was tested as a dilution and therefore not sufficient for hazard assessment.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
- EC Number:
- 230-291-1
- EC Name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
- Cas Number:
- 7011-83-8
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 5-hexyldihydro-5-methylfuran-2(3H)-one
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.19-2.51 kg
- Housing: individually, in suspended metal cages
- Diet: ad libitum, Rabbit Diet, A.W. Tindall Limited, Holbeach, Lincolnshire
- Water: ad libitum, tap water
- Acclimation period: min. 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.5 ± 1.5
- Humidity (%): 65-68
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: liquid paraffin
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL
- Concentration: undiluted (100 %) and 75 % for 1 animal in range finding test; 50, 25 and 10 % for 1 animal in range finding test; main study 25 % were used. - Duration of treatment / exposure:
- Range finding test: 24 h
Main study: 4, 12 and 24 h - Observation period:
- 72 h
Observations done at 1, 24, 48 and 72 h after removal - Number of animals:
- Range finding test: 2 (sex not specified)
Main study: 3 (sex not specified) - Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm2
- Type of wrap: surgical gauze two layers thick secured with a cross of Sleek adhesive strapping, in addition elasticated corset (Tubigrip)
REMOVAL OF TEST SUBSTANCE
- Washing: gentle swabbing with cotton wool soaked in lukewarm water
- Time after start of exposure: immediately after 24 h (Range finding test) or 4 h (main study) treatment
SCORING SYSTEM: Draize J.H. (1959)1959), Association of Food and Drug Officials of the United States, Austin, Texas, "The Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" Details on scouring system see "Any other information"
Interpretation of Results:
For each test material concentration the scores for erythema and oedema at the 24 and 72 hour readings were totaled for the three test rabbits (12 values). This total was divided by 6 to give the Primary Cutaneous Irritation Index of each of the four concentrations. This index was used to classify the skin irritation properties of each test material concentration according to the following scheme (after Draize J.H. (1959) Association of Food and Drug Officials of the United States, Austin, Texas, "The Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics")
Details on Primary Cutaneous Irritation Index interpretation see "Any other information"
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 12 h exposure
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 24 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 12 h exposure
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 24 h exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 4 h exposure
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 4 h exposure
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 25 %, 4 h exposure
Any other information on results incl. tables
Range finding test
Animal | Concentration [%] | Timepoint [h] | Erythema score (of max. 4) | Edema score (of max. 4) |
1 | 100 | 1 | 1.00 | 0 |
75 | 1 | 1.00 | 0 | |
Control | 1 | 0 | 0 | |
2 | 50 | 1 | 1.00 | 0 |
25 | 1 | 0.00 | 0 | |
10 | 1 | 0.00 | 0 | |
Control | 1 | 0 | 0 |
Mean scores
25 % with an exposure time of [h] | Mean Erythema score (24/48/72 h) | Mean Edema score (24/48/72 h) |
4 | 0.00 | 0.00 |
12 | 0.00 | 0.00 |
24 | 0.00 | 0.00 |
Vehicle only: 24 | 0.00 | 0.00 |
Individual scores
Animal | 25 % with an exposure time of [h] | Timepoint [h] | Erythema score (of max. 4) | Edema score (of max. 4) |
1 | 4 | 1 | 0.00 | 0 |
24 | 0.00 | 0 | ||
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
12 | 1 | 0.00 | 0 | |
24 | 0.00 | 0 | ||
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
24 | 24 | 0.00 | 0 | |
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
Vehicle only: 24 | 24 | 0.00 | 0 | |
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
2 | 4 | 1 | 0.00 | 0 |
24 | 0.00 | 0 | ||
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
12 | 1 | 0.00 | 0 | |
24 | 0.00 | 0 | ||
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
24 | 24 | 0.00 | 0 | |
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
Vehicle only: 24 | 24 | 0.00 | 0 | |
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
3 | 4 | 1 | 0.00 | 0 |
24 | 0.00 | 0 | ||
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
12 | 1 | 0.00 | 0 | |
24 | 0.00 | 0 | ||
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
24 | 24 | 0.00 | 0 | |
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 | ||
Vehicle only: 24 | 24 | 0.00 | 0 | |
48 | 0.00 | 0 | ||
72 | 0.00 | 0 | ||
mean (24/48/72h) | 0.00 | 0.00 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- A study to determine the skin irritation potential of the test substance in rabbits was conducted and a non-irritating effect at a concentration of 25 % was established.
- Executive summary:
A skin irritation test was performed. A range finding test with 2 animals was conducted. The exposure time was 24 h and concentrations 100, 75, 50, 25 and 5 or 10 % were applied. The range finding test revealed a very slight erythema reaction to concentrations of 100, 75 and 50 % test substance. The main study was conducted using 3 rabbits with the highest non irritating concentration from the range finding test of 25 % and exposure times of 4, 12 and 24 hours. The animals were observed for 72 hours. The mean erythema and edema score for 24/48/72h were 0 for all exposure times. The erythema and the edema score for animal 1 for 24/48/72h with 25 % test substance was 0 for all exposure durations. The erythema and the edema score for animal 2 for 24/48/72h with 25 % test substance was 0 for all exposure durations. The erythema and the edema score for animal 3 for 24/48/72h with 25 % test substance was 0 for all exposure durations. Due to these results the test substance was found to be not skin irritating and without classification at 25 %.
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