Registration Dossier
Registration Dossier
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EC number: 245-605-2 | CAS number: 23356-96-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Het Cam test
- GLP compliance:
- no
- Remarks:
- (study performed according to SOP in a laboratory that conforms to GLP but report not audited by the QAU)
Test material
- Reference substance name:
- L-(pyrrolidin-1-yl)methanol
- EC Number:
- 245-605-2
- EC Name:
- L-(pyrrolidin-1-yl)methanol
- Cas Number:
- 23356-96-9
- Molecular formula:
- C5H11NO
- IUPAC Name:
- L-(pyrrolidin-1-yl)methanol
Constituent 1
Results and discussion
In vitro
Results
- Irritation parameter:
- other: in vitro ocular test (Het Cam test)
- Run / experiment:
- Irritant to the eye
- Remarks on result:
- positive indication of irritation
- Remarks:
- value not provided
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- PROL was found irritant in the ocular in vitro Het Cam test and does require labeling with classification R41/H318 (category 1, severely irritant to the eye) of the GHS.
- Executive summary:
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