Registration Dossier
Registration Dossier
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Reactions mass of N-{2-[(4-bromo-6-substituted-2-alkyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)diazenyl]-[alkyl(2-methoxyalkyl)amino]phenyl}acetamide) and N-{2-[(4-bromo-6-substiuted-2-alkyl-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl)diazenyl]-[alkyl(2-hydroxy-3-phenoxypropyl)amino]phenyl}acetamide
EC number: - | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Determination of the partition coefficient of FTA 41044/A TE using the HPLC method.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.01
- at the temperature of:
- 30 °C
Additional information
The determination was carried out using the HPLC Method, designed to be compatible with Method A8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004.
The test system consisted of a high performance liquid chromatograph with a suitable detector (UV/VIS). A reverse phase HPLC column with a very low percentage of polar groups was used (e.g. C8, C18). The mobile phase contained at least 25% aqueous phase.
Discussion
The result from the preliminary assessment indicated that the HPLC method was the most suitable for determination of partition coefficient.
Testing was carried out at approximately neutral pH, with the test item in a non-ionized form.
The chromatography of the test item showed two sharp main peaks (and numerous smaller peaks) with well-defined and reproducible retention times. The HPLC method was therefore considered to be suitable for the purpose of the test.
Conclusion
The partition coefficient of the test item has been determined to be in the range 936 to 2.85 x 105, log10Pow in the range 2.97 to 5.45. Using area normalization, 97.4 % of the test item gave a log10 Powvalue in the range 5.01 to 5.45.
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