Registration Dossier
Registration Dossier
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EC number: 211-051-5 | CAS number: 628-71-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: detailed report not available: information about purity of the substance missing; bodyweight and age of the animals missing, detailed results missing
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The studies were divided into two phases:
- Dose-ranging study using one or two pairs of rats at 500, 2000, 5000, 10000 and 15000 mg/kg with
observation up to 14 days. When one or more deaths occurred in circumstances clearly indicating a response to treatment, that is, severe adverse
signs within the same and higher dosage groups, animals from all these groups were subjected to euthanasia on humanitarian grounds.
- Confirmation of the maximum non-lethal dose using 5F and
5M rats with observation as in above - GLP compliance:
- no
- Test type:
- other: not available
- Limit test:
- no
Test material
- Reference substance name:
- Hept-1-yne
- EC Number:
- 211-051-5
- EC Name:
- Hept-1-yne
- Cas Number:
- 628-71-7
- Molecular formula:
- C7H12
- IUPAC Name:
- hept-1-yne
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 500, 2000, 5000, 10000 and 15000 mg/kg
- No. of animals per sex per dose:
- 2 per sex per dose in first step
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD 50 is above 5000 mg/kg bw
- Executive summary:
-
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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