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Diss Factsheets
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EC number: 203-007-9 | CAS number: 102-13-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted in 1973.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Very brief results table from an older study conducted prior to development of GLP and current guidlines, information on methodology is minimal
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was conducted prior to development of current guidelines but is broadly comparable to OECD 401. An acute oral study (limit test) was conducted in 10 rats.
- GLP compliance:
- no
- Remarks:
- Conducted prior to development of GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Isobutyl Phenyl Acetate
- IUPAC Name:
- Isobutyl Phenyl Acetate
- Test material form:
- liquid
- Details on test material:
- Identification: Isobutyl phenyl acetate
Commercial name: 2-methylpropyl phenylacetate
Chemical name: 2-methylpropyl phenylacetate
Empirical formula: C12H16O2
Molecular weight: 192.26 g/mol
EC No.: 203-007-9
CAS No.: 102-13-6
Appearance/physical state: Clear colorless liquid
Batch: SC00010162
Purity: 100%
Expiry date: 31 December 2015
Storage conditions: Room temperature in the dark
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No information available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- 10 rats were administed the test substance by oral gavage
- Doses:
- 5 g/kg (equivalent to approximately 5000 mg/kg)
- No. of animals per sex per dose:
- 10 rats were used, sex was not specified
- Control animals:
- no
- Details on study design:
- Rats were observed for signs of toxicity and mortality for 14 days after administration
- Statistics:
- Not required.
Results and discussion
- Preliminary study:
- A preliminary study was not conducted
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality at the limit dose
- Mortality:
- No mortalities
- Clinical signs:
- No clinical signs were observed
- Body weight:
- No information given
- Gross pathology:
- No information given
- Other findings:
- No other findings reported.
Any other information on results incl. tables
No further information available.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 of isobutyl phenylacetate in rats was found to be greater than 5000 mg/kg bw.
- Executive summary:
The acute oral toxicity of isobutyl phenylacetate was evaluated in 10 rats. The study was conducted prior to the development of GLP/guidelines. The test substance was administered orally at the limit dose of 5000 mg/kg bw. The rats were observed for clinical signs of toxicity and mortality for 14 days after administration. There were no mortalities, and no signs of toxicity were observed. The acute oral LD50 of isobutyl phenylacetate in rats was found to be greater than 5000 mg/kg bw.
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