Registration Dossier
Registration Dossier
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EC number: 401-460-9 | CAS number: 82560-06-3 128719
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Adequacy of study:
- other information
Data source
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Buehler
- Principles of method if other than guideline:
- This assay is a minor variant of the "more sensitive" version of the Buehler assay (Arch. Dermatol. 1965,91,171-175). Induction was by dosing on days 1,3,5,8 10, and 12 (6 induction doses), with challenge on day 22. Dinitrochlorobenzene gave the expected response. The UK CA therefore considers that the test is an acceptable alternative under Annex V guidelines (see O.J. L251 pp 115-116).
- GLP compliance:
- yes
- Type of study:
- Buehler test
Results and discussion
Any other information on results incl. tables
Test reference: 4107 SKIN SENS.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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