Registration Dossier
Registration Dossier
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EC number: 247-557-8 | CAS number: 26264-06-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- MSDS Rhodacal CA/70
- Author:
- Rhodia
- Year:
- 1 998
- Bibliographic source:
- Product Safety labs
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Defined oral LD50. Adapted from appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, by the Association of Food and Drug Officials of the United States, 1965.
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Calcium dodecylbenzenesulphonate
- EC Number:
- 247-557-8
- EC Name:
- Calcium dodecylbenzenesulphonate
- Cas Number:
- 26264-06-2
- Molecular formula:
- C36H58CaO6S2
- IUPAC Name:
- calcium bis(2-undecylbenzene-1-sulfonate)
- Test material form:
- solid: compact
- Details on test material:
- - Name of test material (as cited in study report):Benzenesulfonic acid, dodecyl-, calcium salt
Benzenesulfonic acid, dodecyl-,calcium salt), purity 69-71%.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rat (Sprague-Dawley), weight 200-300 g.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Single dose by oral gavage of 1.0, 1.5, 2.0, 2.5 and 3.0 mL/kg bw.
- Doses:
- 1.0, 1.5, 2.0, 2.5 and 3.0 mL/kg bw.
- No. of animals per sex per dose:
- 5/sex/dose group.
- Control animals:
- yes
- Details on study design:
- Mortality/clinical signs daily for 14 days. Body weight on day 0 and 14. Macroscopy on animals that died.
- Statistics:
- Litchfield-Wilcoxin (Probit analysis).
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 300 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- Motaliity was not affected.
- Clinical signs:
- other: A high incidence of diarrhea was noted with the use of the higher concentration. Those rats which succumbed appeared to be weak and showed reduced voluntary activity prior to death.
- Gross pathology:
- No significant gross abnormalities were seen at autopsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral LD50 in male/female rats is 1300 mg/kg bw. No significant gross abnormalities were seen at autopsy.
LD50-rat 1.8 mL/kg ⇔ 1.3 g a.i./kg = 1300 mg/kg bw - Executive summary:
The acute oral LD50 in male/female rats is 1300 mg/kg bw. No significant gross abnormalities were seen at autopsy.
LD50-rat 1.8 mL/kg ⇔ 1.3 g a.i./kg = 1300 mg/kg bw
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