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EC number: 257-399-1 | CAS number: 51765-51-6
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradability of N-(2-phenoxyphenyl)methanesulfonamide is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor (2017). Test substance undergoes 15.6% degradation by BOD in 28 days.Thus, based on percentage degradation, the test chemical N-(2 -phenoxyphenyl)methane sulfonamide was estimated to be not readily biodegradable in water.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound N-(2 -phenoxyphenyl)methanesulfo namide (CAS No. 51765 -51 -6). If released in to the environment, 16.3% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of N-(2-phenoxyphenyl)methanesulfonamide in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of N-(2-phenoxyphenyl)methanesulfonamide in sediment is estimated to be 337.5 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.326%), indicates that N-(2-phenoxyphenyl)methanesulfonamide is not persistent in sediment.
Biodegradation in soil
The half-life period of N-(2-phenoxyphenyl)methanesulfonamide (CAS No.51765 -51 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 83.3% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of N-(2-phenoxyphenyl)methanesulfonamide in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of N-(2-phenoxyphenyl)methanesulfonamide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water
Predicted data for the target compound N-(2-phenoxyphenyl)methanesulfonamide (CAS No. 51765-51-6) and various study for its read across substance were reviewed for the biodegradation end point which are summarized as below:
For target chemical N-(2-phenoxyphenyl)methanesulfonamide(CAS No. 51765-51-6), biodegradability is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor (2017). Test substance undergoes 15.6% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical N-(2 -phenoxyphenyl)methane sulfonamide was estimated to be not readily biodegradable in water.
Estimation Programs Interface Suite (EPI suite, 2017) was run to predict the biodegradation potential of the test compound N-(2-phenoxyphenyl)methanesulfonamide (CAS no. 51765 -51 -6) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that N-(2 -phenoxyphenyl)methanesulfonamide is expected to be not readily biodegradable.
In a weight of evidence study from authoritative database (J-CHECK, 2016), experiment was conducted for 28 days for evaluating the percentage biodegradability of read across substance 1-methyl-3-phenoxybenzene (CAS no. 3586-14-9). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 2% and 1% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, 1 -methyl-3 -phenoxybenzene is considered to be not readily biodegradable in nature.
For another read across chemical N-butylbenzenesulfonamide (CAS no. 3622 -84 -2), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 0% and 1% by BOD, HPLC and TOC removal parameter in 28 days. Thus, based on percentage degradation, N-butylbenzenesulfonamide is considered to be not readily biodegradable in nature.
Another biodegradation study for the same read across substance N-butylbenzenesulfonamide (CAS no. 3622-84-2) was conducted for 28 days for evaluating the percentage biodegradability of substance (U.S. Environmental Protection Agency, 2016).The study was performed according to OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test) at a temperature of20-23°C.Initial test substance conc. used in the study was 45 and 45.2 mg/l (mg CO2/l) & 21.8 and 21.75 mg/l (based on test mat.), respectively. Activated sludge was used as a test inoculum obtained fromsewage treatment plant. Concentrated sludge (6.5 g solids/L) was left to settle for 30 min; the decanted liquid was used as inoculum (7.65 ml/L mineral medium).Sampling was carried out on day 1, 4, 6, 8, 11, 14, 18, 22, 26 and 28, respectively. Sodium acetate of conc. 40.2 mg/l was used as a reference substance for the study. Reference substance undergoes percentage degradation of 105% after 28 days. The percentage degradation of read across substance was determined to be 12% and 23% byCO2 evolution in 28 days. Thus, based on percentage degradation, N-butylbenzenesulfonamide is considered to be not readily biodegradable in nature.
For the same read across chemical N-butylbenzenesulfonamide (CAS no. 3622-84-2) from secondary source (High Production Volume Challenge Program, 2016), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability. The study was performed according to OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test). Initial test substance conc. used in the study was 21.5 mg/l. Activated sludge was used as a test inoculum. In the toxicity control more than 25% degradation occurred within 14 days (based on ThCO2). Therefore, the test substance was assumed to be not inhibitory. The percentage degradation of read across substance was determined to be18% byCO2 evolution parameter in 28 days. Thus, based on percentage degradation, N-butylbenzenesulfonamide is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical N-(2-phenoxyphenyl)methanesulfonamide (fromOECD QSAR toolbox version 3.3 and EPI Suite, 2017) and for its read across substance (from authoritative database J-CHECK, 2016 and secondary source High Production Volume Challenge Program, 2016), it can be concluded that the test substance N-(2-phenoxyphenyl)methanesulfonamide can be expected to be not readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound N-(2 -phenoxyphenyl)methanesulfo namide (CAS No. 51765 -51 -6). If released in to the environment, 16.3% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of N-(2-phenoxyphenyl)methanesulfonamide in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of N-(2-phenoxyphenyl)methanesulfonamide in sediment is estimated to be 337.5 days (3240 hrs). However, as the percentage release of test chemical into the sediment is less than 1% (i.e, reported as 0.326%), indicates that N-(2-phenoxyphenyl)methanesulfonamide is not persistent in sediment.
Biodegradation in soil
The half-life period of N-(2-phenoxyphenyl)methanesulfonamide (CAS No.51765 -51 -6) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 83.3% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of N-(2-phenoxyphenyl)methanesulfonamide in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of N-(2-phenoxyphenyl)methanesulfonamide, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substance N-(2 -phenoxyphenyl)methanesulfonamide can be considered to be not readily biodegradable in nature.
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