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EC number: 250-333-2 | CAS number: 30772-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 April 1988 - 3 June 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliability 1 is assigned because the study is conducted according to OECD 401 guideline and in compliance with GLP, without deviations that influence the quality of the results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Octahydro-4,7-methano-1H-indenecarbaldehyde
- EC Number:
- 250-333-2
- EC Name:
- Octahydro-4,7-methano-1H-indenecarbaldehyde
- Cas Number:
- 30772-79-3
- Molecular formula:
- C11H16O
- IUPAC Name:
- (1R,2S,3S,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-3-carbaldehyde; bis((1R,2S,4R,6R,7S)-tricyclo[5.2.1.0²,⁶]decane-4-carbaldehyde)
- Test material form:
- other: colourless, clear, slightly oily liquid
- Details on test material:
- - Name of test material (as cited in study report): Formyltricyclodecan
- Storage condition of test material: at normal room temperature, in darkness.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Firma Charles River Wiga, Sandhofer Weg 7, 8714 Sulzfeld
- Weight at study initiation: males 217-223 g, females: 170-188 g
- Fasting period before study: 16 hours
- Housing: collective caging (max. 5) in Macrolon type III cages
- Diet: ad libitum, pellets (Ssniff-R diet for rats only)
- Water: ad libitum, tap water
- Acclimation period: minimum 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20±2
- Humidity (%): 50-80
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: May 6th 1988 To: May 25th 1988
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 0.45 mL (dosing 2 ml/kg bw, density = 1.0374)
- Doses:
- 2075 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Clinical signs were observed 10 minutes, 30 minutes, 1 hours, 2 hours, 3 hours, 6 hours, 24 hours, 48 hours and afterwards daily up to day 14. Body weights were recorded on day 0 and 14 (termination).
- Necropsy of survivors performed: yes
- Examinations performed: clinical signs, body weight, gross necropsy (cranial, thoracic and abdominal cavities).
Results and discussion
- Preliminary study:
- Preliminary study showed no mortalities.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: Slight reduced activity (apathy), partly obvious disturbance of coordination with abnormal body posture. First symptoms were observed 10 minutes after administration and lasted up to 6 hours in decreasing intensity. No clinical signs were noted after this
- Gross pathology:
- Necropsy showed no macroscopic findings in the cranial, thoracic and abdominal cavities.
Any other information on results incl. tables
Results of the preliminary study indicated that the acute median lethal oral dose of the test substance was >2000 mg/kg bw, as no mortality was observed in the treated animals (2 females).
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity test showed an LD50 of >2000 mg/kg bw. Based on these results, the substance does not need to be classified for acute oral toxicity according to EU classification criteria.
- Executive summary:
In this study, 10 rats (5 males and 5 females) were administered the substance at a single dose level of 2075 mg/kg bw. The rats showed no mortality, but some clinical signs were noted from 10 minutes up to 6 hours after treatment. A body weight increase was noted in all rats during the observation period (14 days). Necropsy was performed by opening the abdominal-, cranial- and thoracic cavity, but no abnormalities were found. The acute oral LD50 for the substance in male and female rats was determined to be >2000 mg/kg bw (>2075 mg/kg bw).
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