Registration Dossier
Registration Dossier
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EC number: 228-726-5 | CAS number: 6337-43-5
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
No test item related deaths occurred during the study period. The animals treated with the test item did not show any clinical signs during the course of the study. The substance showed skin sensitizing properties in the GPMT according to the current OECD guidelines. Therefore, the substance has to be classified as a skin sensitizer.
Migrated from Short description of key information:
The sensitization potential of the substance was investigated according to OECD Guideline 406. The test item concentrations chosen for the GPMT test were 1% and 50% for the intrcutaneous/epidermal induction and 15% for the challenge.
Justification for selection of skin sensitisation endpoint:
Guideline-conform study under GLP without deviations.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The substance showed skin sensitizing properties in the Guinea pig Maximization Test according to the current OECD guidelines. Therefore, the substance has to be classified as a skin sensitizer Cat. 1A (H317 - May cause an allergenic skin reaction) according to the criteria laid down in the EU Classification Labelling and Packaging Regulation (1272/2008/EC).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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