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EC number: 208-523-8 | CAS number: 532-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Amended Safety Assessment of Sodium Polynaphthalene sulfonate and Sodium Naphthalenesulfonate
- Author:
- Cosmetic Ingredient Review Expert Panel
- Year:
- 2 003
- Bibliographic source:
- International Journal of Toxicology, 22(Suppl. 2):37–44, 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- To evaluate the skin sensitization property of Sodium 2-naphthalenesulfonate in Guinea pigs.
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- Sodium naphthalene-2-sulphonate
- EC Number:
- 208-523-8
- EC Name:
- Sodium naphthalene-2-sulphonate
- Cas Number:
- 532-02-5
- Molecular formula:
- C10H8O3S.Na
- IUPAC Name:
- sodium naphthalene-2-sulphonate
- Reference substance name:
- Sodium 2-naphthalenesulfonate
- IUPAC Name:
- Sodium 2-naphthalenesulfonate
- Details on test material:
- Details on test material
- Name of test material (as cited in study report): sodium 2-naphthalenesulfonate
- Molecular formula (if other than submission substance): C10H8O3S.Na
- Molecular weight (if other than submission substance): 230.23 g/mol
- Substance type: Organic
- Physical state: No data available.
Purity
- Impurities (identity and concentrations): Not more than 0.5% sulfate (as sodium sulfate); not more than 20 mg/kg of heavy metals; and not more than 2 mg/kg arsenic.
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Petroleum jelly
- Concentration / amount:
- Induction exposure: 0.5 g of SNS at a concentration of 30% (w/w) diluted in petroleum jelly.
Challenge exposure: 0.1 g of SNS at a concentration each of 30%, 10%, 3% (w/w) diluted in the petroleum jelly.
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: Petroleum jelly
- Concentration / amount:
- Induction exposure: 0.5 g of SNS at a concentration of 30% (w/w) diluted in petroleum jelly.
Challenge exposure: 0.1 g of SNS at a concentration each of 30%, 10%, 3% (w/w) diluted in the petroleum jelly.
- No. of animals per dose:
- Induction exposure: 10 animals
Challenge exposure: 10 animals - Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures:3 times
- Exposure period: 6 hour
- Test groups: Ten animals
- Control group: Ten animals
- Site: Flank
- Frequency of applications: Once a week
- Duration: 3 weeks.
- Concentrations: 0.5 g of SNS at a concentration of 30% (w/w) diluted in petroleum jelly.
B. CHALLENGE EXPOSURE
- No. of exposures: one time
- Day(s) of challenge: Two weeks
- Exposure period: 24 h
- Test groups: Ten animals
- Control group: Ten animals
- Site: Flank
- Concentrations: 0.1 g of SNS at a concentration each of 30%, 10%, 3% (w/w) diluted in the petroleum jelly.
- Evaluation (hr after challenge): 24 and 48 h - Challenge controls:
- No data available.
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.1 g of SNS at a concentration each of 30%, 10%, 3% (w/w) diluted in the petroleum jelly
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No response
- Remarks on result:
- other: see Remark
- Remarks:
- Reading: 1st reading. . Hours after challenge: 48.0. Group: test group. Dose level: 0.1 g of SNS at a concentration each of 30%, 10%, 3% (w/w) diluted in the petroleum jelly. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No response.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Sodium 2-naphthalenesulfonate was found to be not sensitizing in Guinea pigs
- Executive summary:
Skin sensitization was observed for Sodium 2-naphthalenesulfonate in Guinea pigs by delayed contact hypersensitivity reaction. Ten animals were in the treatment group and 10 in the control group. The test site on the flank was clipped and shaved and 0.5 g of SNS at a concentration of 30% (w/w) (diluted in petroleum jelly) was applied for 6 h under a closed patch, once a week, for 3 weeks. A control site received only the petroleum jelly. Two weeks after the last application, 0.1 g each of 30%, 10%, 3%, or the petroleum jelly were applied to the shaved skin and left for 24 h under a closed patch. Skin reactions were scored on a −, ±, +, ++, +++ scale at 24 and 48 h. In no case was there a positive response, leading the authors to conclude that SNS has no potential to induce delayed contact hypersensitivity.
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