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EC number: 233-546-5 | CAS number: 10226-30-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Aquatic toxicity for 48hrs. study was predicted to assess toxic effects of the test compound 6-Chlorohexan-2-one(CAS No. 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on Tetrahymena pyriformis in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 6-Chlorohexan-2-one(CAS No. 10226-30-9) was estimated to be 1210.713867188 mg/l on the basis of growth inhibition. Thus, based on this value, it can be concluded that the test chemical can be considered as non-toxic to micro organisms and thus cannot be classified as hazardous as per the CLP criteria.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 1 210.71 mg/L
Additional information
Various data for the target chemical 6-Chlorohexan-2-one (CAS No. 10226-30-9) and read across were reviewed for toxicity to micro organism endpoint to summarize the following information:
Aquatic toxicity for 48hrs. study was predicted to assess toxic effects of the test compound 6-Chlorohexan-2-one(CAS No. 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on Tetrahymena pyriformis in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 6-Chlorohexan-2-one(CAS No. 10226-30-9) was estimated to be 1210.713867188 mg/l on the basis of growth inhibition. Thus, based on this value, it can be concluded that the test chemical can be considered as non-toxic to micro organisms and thus cannot be classified as hazardous as per the CLP criteria.
In experimental study the read across substance 2-Nonanone (Cas no. 821-55-6) indicate that the toxicity to micro-organisms study was conducted onTetrahymena pyriformisfor 48 hrs. Stock solutions of test chemical was prepared in dimethyl sulfoxide (DMSO) at conc. of 2.5, 5, 10, 25 or 50 mg/l. The volume of stock solution added to each test flask did not exceed 0.35 ml, an amount that does not alterTetrahymenapopulation growth. Based on growth inhibition of test organism, the IGC50 value was found to be 449 mg/l. (SAR end QSAR in Environmental Research, Vol. 3, pp. 27-36, 1995)
Other experimental result from Toxicology Methods, Vol. 7, Pg. no. 289-309, 1997 for read across 2-Octanone (Cas no. 111-13-7) indicate that the Toxicity to micro-organisms study was conducted onTetrahymena pyriformisstrain GL for 40 hrs. The assay was conducted in a buffered medium under static conditions.The 50% inhibitory growth concentration in mg/l (IGC50) and the 95% fiducial interval are determined for each test compound. The IGC50 was calculated with the probit procedure. Based on growth inhibition of test organism, the IGC50 value was found to be 181.1 and 90.7 mg/l, respectively.
From overall above available results the it is concluded that the test substance 6-Chlorohexan-2-one (CAS No. 10226-30-9) is non toxic to micro organisms.
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