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Diss Factsheets

Physical & Chemical properties

Density

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Reference
Endpoint:
density, other
Remarks:
density
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
GLP compliance:
no
Type of method:
pour and tap (for solids)
Key result
Type:
pour density
Density:
0.625 g/cm³
Temp.:
30.1 °C
Remarks on result:
other: 975.5 hPa
Key result
Type:
tap density
Density:
0.731 g/cm³
Temp.:
30.1 °C
Remarks on result:
other: 975.5 hPa

TEST ITEM DESCRIPTION AND RESULTS :

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details

Observations

Remarks if, any

Guideline

OECD 109

1stReading

2ndReading

 

 

 

Method

Test methods: Pour density and tapped density of powders”recommended inThe International Pharmacopoeia, Fourth Edition, 2014[1]

 

 

 

Principle of method

The density is calculated from the difference in weight between the full and empty pycnometer and its volume.

 

 

 

 

Test temperature (°C)

-

30.0°C

30.2°C

 

Atmospheric pressure (in hPa)

-

975.4 hPa

975.5hPa

 

Volume of test item without tapping (V)

 

 

32 ml

 

32 ml

 

Volume of test item after tapping (V1)

 

27 ml

 

28 ml

 

CALCULATIONS:

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Parameters

Details

Calculated values

Average Density

1st Calculation

2ndCalculation

Pour Density of test item (g/cm3)

m
    v

0.6250 gm/cm3

0.6250 gm/cm3

0.6250gm/cm3

Tap density of test item (g/cm3)

m
    v1

0.7474gm/cm3

0.7142gm/cm3

0.7308 gm/cm3


Conclusions:
The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test chemical was determined to be 0.6250 g/cm³ and 0.7308 g/cm³ at 30.1°C and 975.5 hPa.
Executive summary:

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test chemical was determined to be 0.6250 g/cm³ and 0.7308 g/cm³ at 30.1°C and 975.5 hPa.

Description of key information

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test chemical was determined to be 0.6250 g/cm³ and 0.7308 g/cm³ at 30.1°C and 975.5 hPa.

Key value for chemical safety assessment

Relative density at 20C:
0.625

Additional information

The density of test chemical was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014. The mean pour density and tapped density of the test chemical was determined to be 0.6250 g/cm³ and 0.7308 g/cm³ at 30.1°C and 975.5 hPa.