Registration Dossier
Registration Dossier
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EC number: 931-124-1 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- not required
- Duration of treatment / exposure:
- 3min; 1h and 4h
- Observation period:
- 1h; 24h; 48h; 72h and 7 days
- Number of animals:
- 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No macroscopically visible skin changes were found at the administration sites.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No macroscopically visible skin changes were found at the administration sites
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No macroscopically visible skin changes were found at the administration sites
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No macroscopically visible skin changes were found at the administration sites
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No macroscopically visible skin changes were found at the administration sites
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- The test substance BIBR 1048 Nitril is considered not to be skin irritating or caustic.
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