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Physical & Chemical properties

Water solubility

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Description of key information

The solubility of L-744,341 was determined to be: 0.148 mg/L (pH 4), <0.101 mg/L (pH 7) and <0.110 mg/L (pH9) in media buffered and <0.111 mg/L in Milli-RO Water.  Substance is considered insoluble at < 0.1 mg/L. at pH 7.

in aqueous media buffered to pH 4, pH 7 and pH 9 and Milli-RO Water, respectively.

Key value for chemical safety assessment

Water solubility:
0.101 mg/L
at the temperature of:
25 °C

Additional information

The water solubility of the test substance in media buffered to pH4, pH7 and pH9 and Milli-RO Water has been determined using the flask method as detailed in OECD Guideline 105 (July,1995). No temperature was reported in the report.

Summary of Water Solubility Results:

 

Buffer

 

Timepoint

(h)

Mean Water Solubility (mg.r1)

Overall Mean Water Solubility (mg.1"1)

 

MilliRO Water

24

48

72

<0.102

<0.102

<0.130

 

<0.111

 

pH4

24

48

72

0.139

0.167

0.138

 

0.148

 

pH 7

24

48

72

<0.102

<0.102

<0.100

 

<0.101

 

pH9

24

48

72

<0.102

<0.127

<0.100

 

<0.110