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EC number: 810-201-2 | CAS number: 1050477-27-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes (incl. QA statement)
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- TEST ORGANISMS:
- Type: mixed population of aquatic microorganisms (activated sludge)
- Origin: aeration tank of a wastewater plant treating predominantly domestic sewage (Wupper area water authority, WWTP Odenthal)
- Date of collection: 2016-02-01
- Concentration of inoculum: 30 mg/L suspended solids
PRE-TREATMENT OF THE INOCULUM:
- Before use, the inoculum was stored for one day at room temperature under continuous shaking with aeration
- The sludge was washed twice by adding mineral medium and centrifuging for 10 min at 2000 rpm and 20 °C and decanting off the supernatant
- An aliquot of the wet sludge was dried in order to determine the wet weight / dry weight ratio of the sludge and to prepare a stock suspension (activated sludge) of 3 g dw/L
- The calculated amount of sludge, needed to achieve 300 mL of this stock suspension, was dissolved in mineral medium and then filled up to a defined end volume - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- STUDY PERIOD:
- Start of the experimental phase: 2016-02-01
- End of the experimental phase: 2016-05-19
PRE-TREATMENT OF THE TEST SUBSTANCE:
- 25 mg of the test item were weighed out and filled with 200 mL of mineral medium
- afterwards the volume was made up to 250 mL with mineral medium containing the inoculum to give a test concentration of 100 mg test item/L
PRE-TREATMENT OF THE REFERENCE COMPOUND:
- 25 mg of the reference compound were weighed out and filled with 200 mL of mineral medium
- afterwards the volume was made up to 250 mL with mineral medium containing the inoculum to give a test concentration of 100 mg reference compound/L
PRE-TREATMENT OF THE TOXICITY CONTROL:
- 25 mg of the test item and 25 mg of the reference compound were weighed out and filled with 200 mL of mineral medium
- afterwards the flask volume was made up to 250 mL with mineral medium containing the inoculum to give a test concentration of 100 mg test item and reference compound/L
EXPOSURE CONDITIONS:
- Test volume: 250 mL
- Test apparatus: OxiTopControl System (WTW)
- Number of culture flasks/concentration: 3 (test item) 2 (reference compound), 3 (inoculum blank), 1 (toxicity control)
- Mixing: 1 magnetic stirrer per test vessel
- Test performed in closed vessels: Yes
- Incubation temperature : 22 ± 1 °C
- Test temperature: 22+/- 1°C
- pH: 6.9-7.8 (measured in the test flasks after 28 days)
- pH adjusted: no
- Aeration of dilution water: no
- Continuous darkness: yes
SAMPLING
- Sampling frequency: The BOD (in mg O2/L) was measured daily
CONTROL AND BLANK SYSTEM
- Inoculum blank: Blanks with inoculum and without test item were run in parallel (3 replicates) - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- (Acros Organics) Purity: 99.9 %; Batch-No.: A0357641
- Parameter:
- % degradation (O2 consumption)
- Value:
- 6
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 7
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 8
- Sampling time:
- 21 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 8
- Sampling time:
- 28 d
- Details on results:
- The toxicity control exhibited degradation rates > 25 % within 14 days.
- Results with reference substance:
- The reference compound sodium benzoate showed 90 % degradation after 14 days.
- Validity criteria fulfilled:
- yes
- Remarks:
- (-Ready biodegradation of reference compound ¿ 60 % within 14 days. - The toxicity control exhibited degradation rates > 25 % within 14 days. - Replicates difference < 20 %. - Oxygen uptake of the inoculum blank was ¿ 60 mg/L. - No pH influence)
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Rac-Amido-TH-naphthyridin showed 8 % degradation within 28 days. The reference compound was degraded to 90% .
- Executive summary:
The study was conducted in accordance with the Council Regulation (EC) No 440/2008, Method C.4-D 'Manometric Respirometry Test' (2008). This test method is in all essential parts identical with OECD Guideline 301 F (adopted July 1992). A suspension of the Rac-Amido-TH-naphthyridin in a mineral medium was inoculated and incubated for 28 d under aerobic conditions. During this period, degradation was followed by continuous automated BOD determinations. The 28-day degradation was 8 % while a biodegradation of 90% was observed for the positive control (with reference substance). In conclusion the substance is not readily biodegradable under test conditions.
Reference
The oxygen consumed by nitrification was not determined at the end of the study, because no degradation of the test item was observed and the correction for oxygen uptake by nitrification would not have an influence on the results.
Description of key information
Rac-Amido-TH-naphthyridin showed 8 % degradation within 28 days. Thus, the substance is considered to be "not readily biodegradable".
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The reference compound sodium benzoate was degraded to 90%.
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