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EC number: 211-069-3 | CAS number: 629-05-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30.05 - 13.06.1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study performed according to GLP and OECD guidelines
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
- Report date:
- 1995
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Oct-1-yne
- EC Number:
- 211-069-3
- EC Name:
- Oct-1-yne
- Cas Number:
- 629-05-0
- Molecular formula:
- C8H14
- IUPAC Name:
- oct-1-yne
- Details on test material:
- Physical state: colorless liquid
- Analytical purity: 98.2%
- Lot/batch No.: 18084
- Stability under test conditions: stable
- Storage condition of test material: Room temperature, stored away from light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: BRL (Biological Research Laboratories) 4414 Fullinsdorf, Switzerland
- Weight at study initiation: M: approx.145 g, F: approx.129 g
- Fasting period before study: The animals were fasted overnight before treatment, and access to feed was given
about 3 hours after dosing.
- Housing: Macrolon® boxes, type III, with dust-free wood shaving
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +- 2°C
- Humidity (%): 50% +- 10%
- Photoperiod (hrs dark / hrs light): Fluorescent tubes, 12 hours light/dark cycle
IN-LIFE DATES: From: 30.05.1995 To: 13.06.1995
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sodium Carboxylmethylcellulose (CMC) 5 g; Tween 80 4 ml; Benzylalcohol 5 ml; Nacl (0.9%) ad 1000 ml
- Doses:
- 2000 mg/kg body weight
- No. of animals per sex per dose:
- for 2000 mg/kg: 10 animals 5 M + 5 F
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortalities: Daily; Clinical symptoms: Daily (excl. weekend); Body weight development: 2-3 times per week
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,
Results and discussion
- Preliminary study:
- not GLP, not seperately recorded
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: 95% CL not calculated
- Mortality:
- -
- Clinical signs:
- other: Pilo-erection was noted in all animals within a few hours after administration of 1-Octyne. Four out of ten animals were sedated shortly after treatment. All animals recovered within a few hours. No further clinical signs were noted during the observation
- Gross pathology:
- -
- Other findings:
- - Other observations: No uncommon findings were observed at scheduled necropsy.
Any other information on results incl. tables
see attachement "tables"
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Single oral administration of 2000 mg/kg body weight was
tolerated in male and female rats without notable toxicity.
The intermediate 1-Octyne can be classified as a compound which does not
present a significant acute toxic risk if swallowed, according to OECD and EU
guidelines. - Executive summary:
The acute oral toxicity of the flavour intermediate 1 -Octyne, was
investigated in 10 Wistar rats (5 M, 5 F).
Single oral administration of 2000 mg/kg body weight of 1 -Octyne was
tolerated without notable toxicity. Pilo-erection was noted in all animals within a few
hours after treatment. Four out of ten animals were sedated shortly after compound
administration. All animals quickly recovered. No further relevant findings were
noted during the observation period (14 days) or at scheduled necropsy.
The substance can be classified as a compound which does not
present a significant acute toxic risk if swallowed, according to OECD and EU
guidelines.
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