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Diss Factsheets
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EC number: 611-005-8 | CAS number: 53513-80-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-Studie, ausführlich dokumentiert
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- D-Penicillamin-Bleisalz
- IUPAC Name:
- D-Penicillamin-Bleisalz
- Reference substance name:
- Bleisalz der 2-Amino-3-mercapto-3-methylbuttersäure
- IUPAC Name:
- Bleisalz der 2-Amino-3-mercapto-3-methylbuttersäure
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Analytical purity: >99.0%
- Lot/batch No.: 120595
- Storage condition of test material: keine besonderen Maßnahmen
- Charakterisierung: graugelbes Pulver, charakteristischer Geruch
- Summenformel: C5H9NO2PbS
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 0, 32 und 58 mg/L (nominal), nach 0 und 48 Stunden
- Sample storage conditions before analysis: tiefgefroren
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 50 mg Substanz und 50 mg PEG 600 wurden mit künstlichem Süßwasser auf 500 mL aufgefüllt und durch mehrstündiges Rühren gelöst.
- Controls: Hilfsstoffkontrolle 50 mg PEG 600 / 50 mL künstliches Süßwasser; 1 Kontrolle ohne Tiere für Bestimmung der PC-Daten
- Chemical name of vehicle: PEG 600
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Klon 5
- Source: Umweltbundesamt, Institut für Wasser-, Boden- und Lufthygiene, Berlin. In eigener Laborzucht weitergeführt.
- Age at study initiation: 6-24 Stunden
- Feeding during test: keine
ACCLIMATION
- Acclimation conditions: Temperatur 21,0-22,2°C (innerhalb 5 Tage vor Expositionsbeginn), Beleuchtung 12:12 Stunden, M4 Medium
- Type and amount of food: Algen
- Feeding frequency: an 6 Tagen/Woche
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 19,3 - 19,5 °C (0 Stunden)
19,7 - 20,4 °C (48 Stunden) - pH:
- 8,2 - 8,3 (0 Stunden)
8,0 - 8,4 (48 Stunden) - Dissolved oxygen:
- 8,8 - 9,0 mg/L (0 Stunden)
8,8 - 8,9 mg/L (48 Stunden) - Nominal and measured concentrations:
- 85 - 95% (Mittel 91%) der Nominalkonzentrationen wurden gemessen. Die Prüfsubstanz war über den Expositionszeitraum stabil.
- Details on test conditions:
- TEST SYSTEM
- Fill volume: 20 mL
- Aeration: keine
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 5
- No. of vessels per vehicle control (replicates): 5
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: künstliches Süßwasser
- Ca/Mg: 2,04mmol/L Ca, 0,42 mmol/L Mg
TEST CONCENTRATIONS
- Test concentrations: 0, 10, 18, 32, 58, 95 mg/L (nominal) - Reference substance (positive control):
- yes
- Remarks:
- Kaliumdichromat
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 65 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 24 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 95 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 61 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 95 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of control: keine
- Results with reference substance (positive control):
- - EC50/LC50: 1,9 mg/L
Any other information on results incl. tables
Ergebnisse nach 24 und 48 Stunden:
Konzentration (mg/L) |
Mortalität (%) nach 24 Stunden |
Mortalität (%) nach 48 Stunden |
0 |
0 |
0 |
0 (Hilfsstoff) |
0 |
0 |
10 |
0 |
0 |
18 |
0 |
0 |
32 |
0 |
0 |
58 |
30 |
35 |
95 |
95 |
100 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Die 48h-EC50 für Daphnien wurde nach der EU-Methode C.2 getestet und beträgt 61 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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